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On the Lorentzian versus Gaussian Character of Time Domain Spin Echo Signals Sampled via Gradient Echoes: Implications for Iron Deposition Analyses

Institution:
1Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
2Department of Radiology, Children's Hospital, Boston, MA, USA.
Publication Date:
May-2014
Citation:
The International Society for Magnetic Resonance in Medicine 22nd Scientific Meeting & Exhibition, 2014 May, Milan, Italy.
Appears in Collections:
ISMRM
Generated Citation:
Mulkern R.V., Balasubramanian M., Mitsouras D. On the Lorentzian versus Gaussian Character of Time Domain Spin Echo Signals Sampled via Gradient Echoes: Implications for Iron Deposition Analyses. The International Society for Magnetic Resonance in Medicine 22nd Scientific Meeting & Exhibition, 2014 May, Milan, Italy.
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Previous brain iron deposition imaging studies that have estimated R2 and R2* (or R2 ́) simultaneously from multiple gradient echo sampling of either a single spin echo or a free induction decay and the left-side of a spin-echo have assumed Lorentzian frequency distributions for the water resonance [1-6]. It is our purpose to demonstrate that Gaussian distributions, which have a markedly different time domain response, are better suited for these types of studies. This implies that more robust analyses with improved quantitation and separation of reversible and irreversible transverse relaxation processes are possible.