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The Impact of Arterial Input Function Determination Variation on Prostate Dynamic Contrast-Enhanced Magnetic Resonance Imaging Pharmacokinetic Modeling: A Multicenter Data Analysis Challenge

Institution:
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Publication Date:
May-2016
Citation:
The International Society for Magnetic Resonance in Medicine 24th Scientific Meeting & Exhibition, 2016 May, Singapore. P3394.
Appears in Collections:
ISMRM
Sponsors:
P41 EB015898/EB/NIBIB NIH HHS/United States
U01 CA154602/CA/NCI NIH HHS/United States
U01 CA151261/CA/NCI NIH HHS/United States
U01 CA154601/CA/NCI NIH HHS/United States
U01 CA183848/CA/NCI NIH HHS/United States
U01 CA148131/CA/NCI NIH HHS/United States
U01 CA176110/CA/NCI NIH HHS/United States
U01 CA172320/CA/NCI NIH HHS/United States
U01 CA142565/CA/NCI NIH HHS/United States
U01 CA166104/CA/NCI NIH HHS/United States
U01 CA140230/CA/NCI NIH HHS/United States
Generated Citation:
Huang W., Chen Y., Fedorov A., Li X., Jajamovich G., Malyarenko D.I., Aryal M., LaViolette P.S., Oborski M.J., O’Sullivan F., Abramson R.G., Muzi M., Jafari-Khouzani K., Afzal A., Tudorica A. The Impact of Arterial Input Function Determination Variation on Prostate Dynamic Contrast-Enhanced Magnetic Resonance Imaging Pharmacokinetic Modeling: A Multicenter Data Analysis Challenge. The International Society for Magnetic Resonance in Medicine 24th Scientific Meeting & Exhibition, 2016 May, Singapore. P3394.
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Dynamic Contrast-Enhanced MRI (DCE-MRI) pharmacokinetic modeling is widely used to extract tissue specific quantitative parameters. However, the accuracy and precision of these parameters can be affected by many factors, with arterial input function (AIF) determination being a primary source of uncertainties. In this multicenter study, we sought to evaluate variations in DCE-MRI parameters estimated from shared prostate DCE-MRI data as a result of differences in AIFs.