Surgical Planning Laboratory - Brigham & Women's Hospital - Boston, Massachusetts USA - a teaching affiliate of Harvard Medical School

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A Motion-robust Sequence for Combined Thermometry and T2-mapping to Guide and Assess Tissue Damage during Thermal Therapies

Institution:
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Publication Date:
May-2014
Citation:
The International Society for Magnetic Resonance in Medicine 22nd Scientific Meeting & Exhibition, 2014 May, Milan, Italy.
Appears in Collections:
ISMRM
Sponsors:
P41 EB015898/EB/NIBIB NIH HHS/United States
R01 EB010195/EB/NIBIB NIH HHS/United States
R01 CA149342/CA/NCI NIH HHS/United States
Generated Citation:
Mei C-S., Chu R., Panych L.P., Madore B. A Motion-robust Sequence for Combined Thermometry and T2-mapping to Guide and Assess Tissue Damage during Thermal Therapies. The International Society for Magnetic Resonance in Medicine 22nd Scientific Meeting & Exhibition, 2014 May, Milan, Italy.
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There is currently no completely-satisfactory way of detecting tissue damage as it occurs during MR-guided Focused Ultrasound (FUS) surgery. The current standard involves calculating the temperature dose (TD) and selecting a threshold beyond which damage is assumed to have occurred. Although very useful, TD measurements have notable drawbacks: 1) damage is inferred indirectly rather than seen directly in the images, and 2) the entire thermal history of each volume of tissue is needed toward TD calculations. Especially in abdominal organs where motion is problematic, capturing the thermal history of any given piece of moving tissue can be a challenge, and errors readily propagate to all future TD measurements. As tissue damage is believed to be associated with changes in T21, damage could possibly prove visible on a frame-by-frame basis if real-time T2 maps were available. A dual-pathway (PSIF-FISP) thermometry sequence was employed here to provide time-resolved measurements of both temperature and T2 simultaneously. It was tested both with and without motion, during heating experiments.