Summary of group differences. Statistically significant increases in ROI values in elderly relative to young subjects across all phase-guided and FDRI-guided ROIs is shown above in axial views of the cerebrum and brainstem (red box). ROIs obtained from a standard Talairach atlas  are overlaid on the MNI152T1 atlas  for visualization purposes only. Numerical results of all t-tests (requiring p≤0.0125 for significance under one-tailed, Bonferroni-correction for 8 comparisons) are provided in tables 1-4 of the supplemental material. QSIP (d) showed statistically significant increases in QSM values in all five striatal and brain stem nuclei: putamen (yellow), caudate (maroon), globus pallidus (green), red nucleus (red), and substantia nigra (purple), consistent with hypothesized age-dependent iron deposition in these regions. Results for FDRI (a), L1-QSM (b), and QSIP-C (c) show group differences in fewer regions, which may be due to greater variabiliy in ROI estimates obtained with these methods.
The Surgical Planning Laboratory is a research laboratory in the Department of Radiology of Brigham and Women's Hospital. The Core Mission of the SPL is the extraction of medically relevant information from diagnostic imaging data and to concepts of computation and image analysis to new field of biomedical research. The lab collaborates with groups within Brigham and Women's Hospital, with other researchers at the Harvard Medical School, with local universities such as Harvard and MIT, and with clinicians, researchers, and engineers throughout the world.