Surgical Planning Laboratory - Brigham & Women's Hospital - Boston, Massachusetts USA - a teaching affiliate of Harvard Medical School

Surgical Planning Laboratory

Kelly H. Zou, Ph.D., PStat, ASA Fellow (July 1997-September 2006)

E-mail: zou at

Dr. Kelly H. Zou is the Director of Biostatistics, Clinical Research Program, Children's Hospital Boston,Harvard Medical School. In addition, she is an Associate Professor of Radiology,Department of Radiology, Children's Hospital Boston, and a Lecturer of Health Care Policy, Department of Health Care Policy, Harvard Medical School.

Dr. Zou received her B.A. (Summa Cum Laude) in Mathematics from Chaminade University of Honolulu in 1992, M.A. and Ph.D. in Statistics from the University of Rochester in 1994 and 1997, respectively. She completed a joint Postdoctoral Fellowships in Biostatistics and Radiology at Harvard Medical School and Brigham and Women's Hospital in 1999. Since then she has been on the faculty at Harvard Medical School. She was the Principal Statistician, Department of Radiology, Brigham and Women's Hospitalfrom July 1997 to September 2006.

Summary of Research Interests

Dr. Zou's statistical methodological work has been devoted to health care policy and cancer imaging research. She has served as the Principal Investigator of Grant R01-LM007861, entitled "Improved Tumor Resection in Image-Guided Neurosurgery," sponsored by the National Library of Medicine of the National Institutes of Health (NIH/NLM); Grant R01-GM074068, entitled "Bioinformatics Tools for Multi-Center Diagnostic Trials," sponsored by the National Institute of General Medical Sciences (NIH/NIGMS); Grant R03-HS13234, entitled "Bayesian Methods for Sample Size Calculation," sponsored by the Agency for Healthcare Research and Quality(NIH/AHRQ).

Much of her statistical research involves validation problems associated with receiver operating characteristic (ROC) curve analysis, which are useful for evaluating and comparing the accuracies of diagnostic markers or imaging modalities. Her work on ROC analysis has led her to be the recipient of the Stauffer Award for the best article published in Academic Radiology and the winner of multipleAmerican Statistical Association (ASA) poster competitions from 2009 to 2012. She was twice the recipient of the Travel Stipend Award from the Society of Health Services Research in Radiology and Reviewer with Special Distinction Award for "Radiology." Dr. Zou's health care policy research focuses on the design of multi-center health quality of care studies and development of improved methods for reliability measures.

Dr. Zou is an Accredited Professional Statisticians PSTAT and an Statistical Association ASA Fellow. She has been an Associate Editor of "Statistics in Medicine," "Radiology," "Medical Physics," and a Referee for over 10 professional statistical and medical journals. She has served as Vice Chair of the Committee on Applied Statisticians; Member of Statistical Partnerships among Academe, Industry, and Government; Member of the Corporate Sponsorship Committee, Biopharmaceutical Section; Chair of Judiciary Committee, Radiology Alliance to Health Services Research, Association of University Radiologists; Member of the Faculty Taskforce, Joint Committee on the Status of Women, Harvard Medical School and Harvard School of Dental Medicine. She has also been an investigator and author on a number of collaborative medical research projects. For example, she was a statistician on NIH-funded multi-institutional Radiologic Diagnostic Oncology Group (RDOG) and Biomedical Informatics Research Network (BIRN) studies.

Dr. Zou's teaching activities included the development of several courses on statistical methods in clinical research for clinicians and researchers. She is the theme editor and lead author on statistics books entitled "Mathematical and Statistical Methods for Diagnoses and Therapies" by the Oxford University Press. Dr. Zou has been a course developer and statistical seminar instructor both locally and nationally.

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