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Consistent Neuroanatomical Age-related Volume Differences across Multiple Samples

1Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Norway.
2Department of Neuropsychology, Ullevaal University Hospital, Norway.
Elsevier Science
Publication Date:
Volume Number:
Issue Number:
Neurobiol Aging. 2011 May;32(5):916-32.
PubMed ID:
MRI morphometry, Age, Cortex, White matter, Cerebellum, Ventricles, Hippocampus, Amygdala, Thalamus, Basal Ganglia
Appears in Collections:
P41 RR014075/RR/NCRR NIH HHS/United States
R01 NS039581/NS/NINDS NIH HHS/United States
R01 RR013609/RR/NCRR NIH HHS/United States
R01 RR016594/RR/NCRR NIH HHS/United States
R37 AG011230/AG/NIA NIH HHS/United States
Generated Citation:
Walhovd K.B., Westlye L.T., Amlien I., Espeseth T., Reinvang I., Raz N., Agartz I., Salat D.H., Greve D.N., Fischl B., Dale A.M., Fjell A.M. Consistent Neuroanatomical Age-related Volume Differences across Multiple Samples. Neurobiol Aging. 2011 May;32(5):916-32. PMID: 19570593. PMCID: PMC4040218.
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Magnetic resonance imaging (MRI) is the principal method for studying structural age-related brain changes in vivo. However, previous research has yielded inconsistent results, precluding understanding of structural changes of the aging brain. This inconsistency is due to methodological differences and/or different aging patterns across samples. To overcome these problems, we tested age effects on 17 different neuroanatomical structures and total brain volume across five samples, of which one was split to further investigate consistency (883 participants). Widespread age-related volume differences were seen consistently across samples. In four of the five samples, all structures, except the brainstem, showed age-related volume differences. The strongest and most consistent effects were found for cerebral cortex, pallidum, putamen and accumbens volume. Total brain volume, cerebral white matter, caudate, hippocampus and the ventricles consistently showed non-linear age functions. Healthy aging appears associated with more widespread and consistent age-related neuroanatomical volume differences than previously believed.

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