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Brain Regional Lesion Burden and Impaired Mobility in the Elderly

1Center for Neurological Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
2Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
3Department of Neurology, University of Connecticut Health Center, Farmington, CT, USA
4Lahey Clinic, Burlington, MA, USA.
Elsevier Science
Publication Date:
Neurobiol Aging
Volume Number:
Issue Number:
Neurobiol Aging. 2011 Apr;32(4):646-54.
PubMed ID:
Aging, Mobility, Brain, White matter, White matter hyperintensity, Splenium of Corpus Callosum, Corona radiata, Magnetic resonance imaging
Appears in Collections:
P41 RR013218/RR/NCRR NIH HHS/United States
R01 AG022092/AG/NIA NIH HHS/United States
M01 RR006192/RR/NCRR NIH HHS/United States
Generated Citation:
Moscufo N., Guttmann C.R.G., Meier D., Csapo I., Hildenbrand P.G., Healy B., Schmidt J., Wolfson L. Brain Regional Lesion Burden and Impaired Mobility in the Elderly. Neurobiol Aging. 2011 Apr;32(4):646-54. PMID: 19428145. PMCID: PMC2942957.
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This study investigated the relationship of brain white matter (WM) lesions affecting specific neural networks with decreased mobility in ninety-nine healthy community-dwelling subjects ≥75 years old prospectively enrolled by age and mobility status. We assessed lesion burden in the genu, body and splenium of corpus callosum; anterior, superior and posterior corona radiata; anterior and posterior limbs of internal capsule; corticospinal tract; and superior longitudinal fasciculus. Burden in the splenium of corpus callosum (SCC) demonstrated the highest correlation particularly with walking speed (r=0.4, p<10-4), and in logistic regression it was the best regional predictor of low mobility performance. We also found that independent of mobility, corona radiata has the largest lesion burden with anterior (ACR) and posterior (PCR) aspects being the most frequently affected. The results suggest that compromised inter-hemispheric integration of visuospatial information through the SCC plays an important role in mobility impairment in the elderly. The relatively high lesion susceptibility of ACR and PCR in all subjects may obscure the importance of these lesions in mobility impairment.

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Moscufo-NeurobiolAging2009-fig2.jpg (157.154kB)