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A Combined fMRI and DTI Examination of Functional Language Lateralization and Arcuate Fasciculus Structure: Effects of Degree versus Direction of Hand Preference
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Propper R.E.1, O'Donnell L.1, Whalen S.1, Tie Y.1, Norton I.H.1, Suarez R.O.1, Zöllei L.2, Radmanesh A.1, Golby A.J.1
Institution: |
1Golby Neurosurgical Brain Mapping Laboratory, Departments of Neurosurgery and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. ruth.propper@merrimack.edu 2A.A. Martinos Center, Massachusetts General Hospital, Boston, MA, USA |
Publisher: |
Elsevier Science |
Publication Date: |
Jul-2010 |
Journal: |
Brain Cogn |
Volume Number: |
73 |
Issue Number: |
2 |
Pages: |
85-92 |
Citation: |
Brain Cogn. 2010 Jul;73(2):85-92. |
PubMed ID: |
20378231 |
PMCID: |
PMC2880216 |
Keywords: |
Handedness, Language, Arcuate fasciculus, fMRI, DTI |
Appears in Collections: |
NCIGT, SLICER |
Sponsors: |
K08 NS048063/NS/NINDS NIH HHS/United States R25 CA089017/CA/NCI NIH HHS/United States U41 RR019703/RR/NCRR NIH HHS/United States |
Generated Citation: |
Propper R.E., O'Donnell L., Whalen S., Tie Y., Norton I.H., Suarez R.O., Zöllei L., Radmanesh A., Golby A.J. A Combined fMRI and DTI Examination of Functional Language Lateralization and Arcuate Fasciculus Structure: Effects of Degree versus Direction of Hand Preference. Brain Cogn. 2010 Jul;73(2):85-92. PMID: 20378231. PMCID: PMC2880216. |
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The present study examined the relationship between hand preference degree and direction, functional language lateralization in Broca's and Wernicke's areas, and structural measures of the arcuate fasciculus. Results revealed an effect of degree of hand preference on arcuate fasciculus structure, such that consistently-handed individuals, regardless of the direction of hand preference, demonstrated the most asymmetric arcuate fasciculus, with larger left versus right arcuate, as measured by DTI. Functional language lateralization in Wernicke's area, measured via fMRI, was related to arcuate fasciculus volume in consistent-left-handers only, and only in people who were not right hemisphere lateralized for language; given the small sample size for this finding, future investigation is warranted. Results suggest handedness degree may be an important variable to investigate in the context of neuroanatomical asymmetries.
Additional Material
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Propper-BrainCogn2010-fig5.jpg (139.44kB)