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MRI-guided Robotic Prostate Biopsy: A Clinical Accuracy Validation

Institution:
Queen's University, Kingston, Canada. helen@cs.queensu.ca
Publisher:
Int Conf Med Image Comput Comput Assist Interv. MICCAI 2010
Publication Date:
Sep-2010
Volume Number:
13
Issue Number:
Pt 3
Pages:
383-91
Citation:
Int Conf Med Image Comput Comput Assist Interv. 2010 Sep;13(Pt 3):383-91.
PubMed ID:
20879423
PMCID:
PMC2976594
Appears in Collections:
Prostate Group, SLICER
Sponsors:
R01 CA111288/CA/NCI NIH HHS/United States
R01 EB002963/EB/NIBIB NIH HHS/United States
Generated Citation:
Xu H., Lasso A., Vikal S., Guion P., Krieger A., Kaushal A., Whitcomb L.L., Fichtinger G. MRI-guided Robotic Prostate Biopsy: A Clinical Accuracy Validation. Int Conf Med Image Comput Comput Assist Interv. 2010 Sep;13(Pt 3):383-91. PMID: 20879423. PMCID: PMC2976594.
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Prostate cancer is a major health threat for men. For over five years, the U.S. National Cancer Institute has performed prostate biopsies with a magnetic resonance imaging (MRI)-guided robotic system. PURPOSE: A retrospective evaluation methodology and analysis of the clinical accuracy of this system is reported. METHODS: Using the pre and post-needle insertion image volumes, a registration algorithm that contains a two-step rigid registration followed by a deformable refinement was developed to capture prostate dislocation during the procedure. The method was validated by using three-dimensional contour overlays of the segmented prostates and the registrations were accurate up to 2 mm. RESULTS: It was found that tissue deformation was less of a factor than organ displacement. Out of the 82 biopsies from 21 patients, the mean target displacement, needle placement error, and clinical biopsy error was 5.9 mm, 2.3 mm, and 4 mm, respectively. CONCLUSION: The results suggest that motion compensation for organ displacement should be used to improve targeting accuracy.

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Xu-MICCAI2010-fig3.jpg (18.379kB)