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Anisotropy of Transcallosal Motor Fibres Indicates Functional Impairment in Children with Periventricular Leukomalacia

Institution:
1Institute of Clinical Radiology, Ludwig-Maximilians-University, Munich, Germany.
2Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA.
3Pediatric Neurology and Developmental Medicine, Dr von Hauners Children's Hospital, Ludwig-Maximilians-University, Munich, Germany.
4Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University Munich, Germany.
5Department of Neurology, Ludwig- Maximilians-University, Munich, Germany.
6Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, Harvard Medical School, Boston, MA, USA.
Publisher:
Blackwell Publishing
Publication Date:
Feb-2011
Journal:
Dev Med Child Neurol
Volume Number:
53
Issue Number:
2
Pages:
179-86
Citation:
Dev Med Child Neurol. 2011 Feb;53(2):179-86.
PubMed ID:
21121906
PMCID:
PMC3057566
Appears in Collections:
PNL, NA-MIC, SLICER
Sponsors:
K05 MH070047/MH/NIMH NIH HHS/United States
P50 MH080272/MH/NIMH NIH HHS/United States
R01 MH050740/MH/NIMH NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Koerte I.K., Pelavin P., Kirmess B., Fuchs T., Berweck S., Laubender R.P., Borggraefe I., Schroeder S., Danek A., Rummeny C., Reiser M., Kubicki M., Shenton M.E., Ertl-Wagner B., Heinen F. Anisotropy of Transcallosal Motor Fibres Indicates Functional Impairment in Children with Periventricular Leukomalacia. Dev Med Child Neurol. 2011 Feb;53(2):179-86. PMID: 21121906. PMCID: PMC3057566.
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In children with bilateral spastic cerebral palsy (CP), periventricular leukomalacia (PVL) is commonly identified on magnetic resonance imaging. We characterized this white matter condition by examining callosal microstructure, interhemispheric inhibitory competence (IIC), and mirror movements. Method  We examined seven children (age range 11y 9mo-17y 9mo, median age 15y 10mo, four females, three males) with bilateral spastic CP/PVL (Gross Motor Function Classification System level I or II, Manual Ability Classification System level I) and 12 age-matched controls (age range 11y 7mo-17y 1mo, median age 15y 6mo, seven females, five males). Fractional anisotropy of the transcallosal motor fibres (TCMF) and the corticospinal tract (CST) of both sides were calculated. The parameters of IIC (transcranial magnetic stimulation) and mirror movements were measured using a standardized clinical examination and a computer-based hand motor test. Results  Fractional anisotropy was lower in children with bilateral spastic CP/PVL regarding the TCMF, but not the left or right CST. Resting motor threshold was elevated in children with bilateral spastic CP/PVL whereas measures of IIC tended to be lower. Mirror movements were markedly elevated in bilateral spastic CP/PVL. Interpretation  This study provides new information on different aspects of motor function in children with bilateral spastic CP/PVL. Decreased fractional anisotropy of TCMF is consistent with impairment of hand motor function in children with bilateral spastic CP/PVL. The previously overlooked microstructure of the TCMF may serve as a potential indicator for hand motor function in patients with bilateral spastic CP/PVL.

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Koerte-DevChilNeu2011-fig2.jpg (93.553kB)