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Impact of Nonrigid Motion Correction Technique on Pixel-wise Pharmacokinetic Analysis of Free-breathing Pulmonary Dynamic Contrast-enhanced MR Imaging

Institution:
1Center for Pulmonary Functional Imaging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
2Surgical Planning Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
3Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
4Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
5Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Publisher:
Wiley-Liss, Inc.
Publication Date:
Apr-2011
Journal:
J Magn Reson Imaging
Volume Number:
33
Issue Number:
4
Pages:
968-73
Citation:
J Magn Reson Imaging. 2011 Apr;33(4):968-73.
PubMed ID:
21448965
PMCID:
PMC3069717
Keywords:
dynamic contrast-enhanced MRI, pharmacokinetic analysis, nonrigid image registration, solitary pulmonary nodule, motion correction
Appears in Collections:
SNR, NA-MIC, NAC, NCIGT, SLICER, SPL
Sponsors:
P01 CA067165/CA/NCI NIH HHS/United States
P41 EB015902/EB/NIBIB NIH HHS/United States
R21 CA116271/CA/NCI NIH HHS/United States
P41 RR019703/RR/NCRR NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Tokuda J., Mamata H., Gill R.R., Hata N., Kikinis R., Padera R.F., Lenkinski R.E., Sugarbaker D.J., Hatabu H. Impact of Nonrigid Motion Correction Technique on Pixel-wise Pharmacokinetic Analysis of Free-breathing Pulmonary Dynamic Contrast-enhanced MR Imaging. J Magn Reson Imaging. 2011 Apr;33(4):968-73. PMID: 21448965. PMCID: PMC3069717.
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PURPOSE: To investigate the impact of nonrigid motion correction on pixel-wise pharmacokinetic analysis of free-breathing DCE-MRI in patients with solitary pulmonary nodules (SPNs). Misalignment of focal lesions due to respiratory motion in free-breathing dynamic contrast-enhanced MRI (DCE-MRI) precludes obtaining reliable time-intensity curves, which are crucial for pharmacokinetic analysis for tissue characterization. MATERIALS AND METHODS: Single-slice 2D DCE-MRI was obtained in 15 patients. Misalignments of SPNs were corrected using nonrigid B-spline image registration. Pixel-wise pharmacokinetic parameters K(trans), v(e), and k(ep) were estimated from both original and motion-corrected DCE-MRI by fitting the two-compartment pharmacokinetic model to the time-intensity curve obtained in each pixel. The "goodness-of-fit" was tested with χ(2) -test in pixel-by-pixel basis to evaluate the reliability of the parameters. The percentages of reliable pixels within the SPNs were compared between the original and motion-corrected DCE-MRI. In addition, the parameters obtained from benign and malignant SPNs were compared. RESULTS: The percentage of reliable pixels in the motion-corrected DCE-MRI was significantly larger than the original DCE-MRI (P = 4 × 10(-7) ). Both K(trans) and k(ep) derived from the motion-corrected DCE-MRI showed significant differences between benign and malignant SPNs (P = 0.024, 0.015). CONCLUSION: The study demonstrated the impact of nonrigid motion correction technique on pixel-wise pharmacokinetic analysis of free-breathing DCE-MRI in SPNs.

Additional Material
1 File (259.336kB)
Tokuda-JMRI2011-fig2.jpg (259.336kB)