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Diffusion Tensor Imaging of Anterior Commissural Fibers in Patients with Schizophrenia

Institution:
Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Publisher:
Elsevier Science
Publication Date:
Aug-2011
Journal:
Schizophr Res
Volume Number:
130
Issue Number:
1-3
Pages:
78-85
Citation:
Schizophr Res. 2011 Aug;130(1-3):78-85.
PubMed ID:
21561738
PMCID:
PMC3745276
Keywords:
Schizophrenia, Diffusion Tensor Imaging, Anterior commissure, White matter tractography, Fractional Anisotropy (FA), Trace
Appears in Collections:
PNL, NA-MIC, SLICER
Sponsors:
K05 MH070047/MH/NIMH NIH HHS/United States
P50 MH080272/MH/NIMH NIH HHS/United States
R01 MH040799/MH/NIMH NIH HHS/United States
R01 MH050740/MH/NIMH NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Choi H., Kubicki M., Whitford T.J., Alvarado J.L., Terry D.P., Niznikiewicz M.A., McCarley R.W., Kwon J.S., Shenton M.E. Diffusion Tensor Imaging of Anterior Commissural Fibers in Patients with Schizophrenia. Schizophr Res. 2011 Aug;130(1-3):78-85. PMID: 21561738. PMCID: PMC3745276.
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fundamental tenet of the “disconnectivity” theories of schizophrenia is that the disorder is ultimately caused by abnormal communication between spatially disparate brain structures. Given that the white matter fasciculi represent the primary infrastructure for long distance communication in the brain, abnormalities in these fiber bundles have been implicated in the etiology of schizophrenia. Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique that enables the visualization of white matter macrostructure in vivo, and which has provided unprecedented insight into the existence and nature of white matter abnormalities in schizophrenia. The paper begins with an overview of DTI and more commonly used diffusion metrics and moves on to a brief review of the schizophrenia literature. The functional implications of white matter abnormalities are considered, particularly with respect to myelin's role in modulating the transmission velocity of neural discharges. The paper concludes with a speculative hypothesis about the relationship between gray and white matter abnormalities associated with schizophrenia.

Additional Material
1 File (190.793kB)
Choi-SchizophrResTreatment2011-fig1.jpg (190.793kB)