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Fiber Geometry in the Corpus Callosum in Schizophrenia: Evidence for Transcallosal Misconnection
Institution:
 1Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
2Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Heath, Melbourne, VIC, Australia.
3ClinicalNeuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs (VA) Boston Healthcare System, Harvard Medical School Brockton, MA, USA.
4Laboratory of Mathematics in Imaging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
5Golby Laboratory, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
6College of Liberal Arts, University of Massachusetts – Boston, Boston, MA, USA.
Publisher:
 Elsevier Science
Publication Date:
 Oct-2011
Journal:
 Schizophr Res
Volume Number:
 132
Issue Number:
 1
Pages:
 69-74
Citation:
 Schizophr Res. 2011 Oct;132(1):69-74.
PubMed ID:
 21831601
PMCID:
 PMC3172336
Keywords:
 Callosal, Diffusion-Tensor Imaging, Neurodevelopment, Morphometry, White-matter, Genu
Appears in Collections:
PNL, LMI, NA-MIC, NAC, NCIGT, SLICER, SPL
Sponsors:
 K05 MH070047/MH/NIMH NIH HHS/United States
R01 MH040799/MH/NIMH NIH HHS/United States
P41 RR013218/RR/NCRR NIH HHS/United States
P50 MH080272/MH/NIMH NIH HHS/United States
R01 MH074794/MH/NIMH NIH HHS/United States
R01 MH082918/MH/NIMH NIH HHS/United States
R01 MH050747/MH/NIMH NIH HHS/United States
R01 MH050740/MH/NIMH NIH HHS/United States
R03 MH068464/MH/NIMH NIH HHS/United States
R25 CA089017/CA/NCI NIH HHS/United States
T32 MH016259/MH/NIMH NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
 Whitford T.J., Savadjiev P., Kubicki M., O'Donnell L., Terry D.P., Bouix S., Westin C-F., Schneiderman J.S., Bobrow L., Rausch A.C., Niznikiewicz M.A., Nestor P.G., Pantelis C., Wood S.J., McCarley R.W., Shenton M.E. Fiber Geometry in the Corpus Callosum in Schizophrenia: Evidence for Transcallosal Misconnection. Schizophr Res. 2011 Oct;132(1):69-74. PMID: 21831601. PMCID: PMC3172336.
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BACKGROUND: Structural abnormalities in the callosal fibers connecting the heteromodal association areas of the prefrontal and temporoparietal cortices bilaterally have been suggested to play a role in the etiology of schizophrenia. AIMS: To investigate for geometric abnormalities in these callosal fibers in schizophrenia patients by using a novel Diffusion-Tensor Imaging (DTI) metric of fiber geometry named Shape-Normalized Dispersion (SHD). METHODS: DTIs (3T, 51 gradient directions, 1.7mm isotropic voxels) were acquired from 26 schizophrenia patients and 23 matched healthy controls. The prefrontal and temporoparietal fibers of the corpus callosum were extracted by means of whole-brain tractography, and their mean SHD calculated. RESULTS: The schizophrenia patients exhibited subnormal levels of SHD in the prefrontal callosal fibers when controlling for between-group differences in Fractional Anisotropy. Reduced SHD could reflect either irregularly turbulent or inhomogeneously distributed fiber trajectories in the corpus callosum. CONCLUSIONS: The results suggest that the transcallosal misconnectivity thought to be associated with schizophrenia could reflect abnormalities in fiber geometry. These abnormalities in fiber geometry could potentially be underpinned by neurodevelopmental irregularities.

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