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Abnormalities of the Left Temporal Lobe and Thought Disorder in Schizophrenia. A Quantitative Magnetic Resonance Imaging Study

Institution:
Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Publisher:
N Engl J Med
Publication Date:
Aug-1992
Volume Number:
327
Issue Number:
9
Pages:
604-12
Citation:
N Engl J Med. 1992 Aug 27;327(9):604-12.
PubMed ID:
1640954
Appears in Collections:
SPL, NCIGT, PNL
Sponsors:
K01 MH000746/MH/NIMH NIH HHS/United States
K04 NS001083/NS/NINDS NIH HHS/United States
R01 MH040799/MH/NIMH NIH HHS/United States
Generated Citation:
Shenton M.E., Kikinis R., Jolesz F.A., Pollak S.D., LeMay M., Wible C.G., Hokama H.H., Martin J., Metcalf D., Coleman M.J. Abnormalities of the Left Temporal Lobe and Thought Disorder in Schizophrenia. A Quantitative Magnetic Resonance Imaging Study. N Engl J Med. 1992 Aug 27;327(9):604-12. PMID: 1640954.
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Data from postmortem, CT, and magnetic resonance imaging (MRI) studies indicate that patients with schizophrenia may have anatomical abnormalities of the left temporal lobe, but it is unclear whether these abnormalities are related to the thought disorder characteristic of schizophrenia. METHODS. We used new MRI neuroimaging techniques to derive (without knowledge of the diagnosis) volume measurements and three-dimensional reconstructions of temporal-lobe structures in vivo in 15 right-handed men with chronic schizophrenia and 15 matched controls. RESULTS. As compared with the controls, the patients had significant reductions in the volume of gray matter in the left anterior hippocampus-amygdala (by 19 percent [95 percent confidence interval, 3 to 36 percent]), the left parahippocampal gyrus (by 13 percent [95 percent confidence interval, 3 to 23 percent], vs. 8 percent on the right), and the left superior temporal gyrus (by 15 percent [95 percent confidence interval, 5 to 25 percent]). The volume of the left posterior superior temporal gyrus correlated with the score on the thought-disorder index in the 13 patients evaluated (r = -0.81, P = 0.001). None of these regional volume decreases was accompanied by a decrease in the volume of the overall brain or temporal lobe. The volume of gray matter in a control region (the superior frontal gyrus) was essentially the same in the patients and controls. CONCLUSIONS. Schizophrenia involves localized reductions in the gray matter of the left temporal lobe. The degree of thought disorder is related to the size of the reduction in volume of the left posterior superior temporal gyrus.

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