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Human Middle Longitudinal Fascicle: Variations in Patterns of Anatomical Connections

Departments of Psychiatry, Neurology and Radiology Services, Center for Morphometric Analysis, A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Publication Date:
Brain Struct Funct
Volume Number:
Issue Number:
Brain Struct Funct. 2013 Jul;218(4):951-68.
PubMed ID:
Diffusion tensor tractograph, Middle longitudinal fascicle, Angular gyrus, Superior parietal lobule, Superior temporal gyrus, Language
Appears in Collections:
K05 MH070047/MH/NIMH NIH HHS/United States
P50 MH080272/MH/NIMH NIH HHS/United States
R01 MH050740/MH/NIMH NIH HHS/United States
R01 MH074794/MH/NIMH NIH HHS/United States
R21 MH084041/MH/NIMH NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Makris N., Preti M.G., Asami T., Pelavin P., Campbell B., Papadimitriou G.M., Kaiser J., Baselli G., Westin C-F., Shenton M.E., Kubicki M. Human Middle Longitudinal Fascicle: Variations in Patterns of Anatomical Connections. Brain Struct Funct. 2013 Jul;218(4):951-68. PMID: 22782432. PMCID: PMC3500586.
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Based on high-resolution diffusion tensor magnetic resonance imaging (DTI) tractographic analyses in 39 healthy adult subjects, we derived patterns of connections and measures of volume and biophysical parameters, such as fractional anisotropy (FA) for the human middle longitudinal fascicle (MdLF). Compared to previous studies, we found that the cortical connections of the MdLF in humans appear to go beyond the superior temporal (STG) and angular (AG) gyri, extending to the temporal pole (TP), superior parietal lobule (SPL), supramarginal gyrus, precuneus and the occipital lobe (including the cuneus and lateral occipital areas). Importantly, the MdLF showed a striking lateralized pattern with predominant connections between the TP, STG and AG on the left and TP, STG and SPL on the right hemisphere. In light of the results of the present study, and of the known functional role of the cortical areas interconnected by the MdLF, we suggested that this fiber pathway might be related to language, high order auditory association, visuospatial and attention functions.

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