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Practical Considerations in T1 Mapping of Prostate for Dynamic Contrast Enhancement Pharmacokinetic Analyses

1Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
2GE Global Research, Niskayuna, NY, USA.
3Department of Radiology, Harvard Medical School, Children's Hospital, Boston, MA, USA.
Publication Date:
Magn Reson Imaging
Volume Number:
Issue Number:
Magn Reson Imaging. 2012 Nov;30(9):1224-33.
PubMed ID:
T1 mapping, prostate, Dynamic Contrast Enhancement
Appears in Collections:
Prostate Group, NCIGT, SLICER, SPL
U01 CA151261/CA/NCI NIH HHS/United States
P41 RR019703/RR/NCRR NIH HHS/United States
P41 EB015898/EB/NIBIB NIH HHS/United States
R01 CA111288/CA/NCI NIH HHS/United States
P01 CA067165/CA/NCI NIH HHS/United States
Generated Citation:
Fennessy F.M., Fedorov A., Gupta S.N., Schmidt E.J., Tempany C.M., Mulkern R.V. Practical Considerations in T1 Mapping of Prostate for Dynamic Contrast Enhancement Pharmacokinetic Analyses. Magn Reson Imaging. 2012 Nov;30(9):1224-33. PMID: 22898681. PMCID: PMC3466364.
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There are many challenges in developing robust imaging biomarkers that can be reliably applied in a clinical trial setting. In the case of dynamic contrast-enhanced (DCE) MRI, one such challenge is to obtain accurate precontrast T(1) maps for subsequent use in two-compartment pharmacokinetic models commonly used to fit the MR enhancement time courses. In the prostate, a convenient and common approach for this task has been to use the same 3D spoiled gradient-echo sequence used to collect the DCE data, but with variable flip angles (VFAs) to collect data suitable for T(1) mapping prior to contrast injection. However, inhomogeneous radiofrequency conditions within the prostate have been found to adversely affect the accuracy of this technique. Herein we demonstrate the sensitivity of DCE pharmacokinetic parameters to precontrast T(1) values and examine methods to improve the accuracy of T(1) mapping with flip angle-corrected VFA SPGR methods, comparing T(1) maps from such methods with "gold standard" reference T(1) maps generated with saturation recovery experiments performed with fast spin-echo (FSE) sequences.

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Fennessy-MRI2012-Fig6.jpg (177.351kB)