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Reduced Fractional Anisotropy and Axial Diffusivity in White Matter in 22q11.2 Deletion Syndrome: A Pilot Study

Institution:
1Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
2Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.
3Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
4Department of Genetics, Harvard Medical School, Boston, MA, USA.
5Surgical Planning Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Publisher:
Elsevier Science
Publication Date:
Oct-2012
Journal:
Schizophr Res
Volume Number:
141
Issue Number:
1
Pages:
35-9
Citation:
Schizophr Res. 2012 Oct;141(1):35-9.
Links:
http://dx.doi.org/10.1016/j.schres.2012.06.032
PubMed ID:
22863550
PMCID:
PMC3462006
Keywords:
22q11.2 Deletion Syndrome (22q11.2DS), Schizophrenia, Diffusion Tensor Magnetic Resonance Imaging (DT-MRI), Fractional Anisotropy (FA), Radial Diffusivity, Tract-Based Spatial Statistics (TBSS), Axial Diffusivity
Appears in Collections:
PNL, NA-MIC, NAC, SLICER, SPL
Sponsors:
K05 MH070047/MH/NIMH NIH HHS/United States
P41 RR013218/RR/NCRR NIH HHS/United States
P50 MH080272/MH/NIMH NIH HHS/United States
R01 MH050740/MH/NIMH NIH HHS/United States
R01 MH082918/MH/NIMH NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Kikinis Z., Asami T., Bouix S., Finn C.T., Ballinger T., Tworog-Dube E., Kucherlapati R., Kikinis R., Shenton M.E., Kubicki M. Reduced Fractional Anisotropy and Axial Diffusivity in White Matter in 22q11.2 Deletion Syndrome: A Pilot Study. Schizophr Res. 2012 Oct;141(1):35-9. PMID: 22863550. PMCID: PMC3462006.
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Individuals with 22q11.2 deletion syndrome (22q11.2DS) evince a 30% incidence of schizophrenia. We compared the white matter (WM) of 22q11.2DS patients without schizophrenia to a group of matched healthy controls using Tract-Based-Spatial-Statistics (TBSS). We found localized reduction of Fractional Anisotropy (FA) and Axial Diffusivity (AD; measure of axonal integrity) in WM underlying the left parietal lobe. No changes in Radial Diffusivity (RD; measure of myelin integrity) were observed. Of note, studies in chronic schizophrenia patients report reduced FA, no changes in AD, and increases in RD in WM. Our findings suggest different WM microstructural pathology in 22q11.2DS than in patients with schizophrenia.

Additional Material
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KikinisZ-SchizophrRes2012-fig1.jpg (137.915kB)