Surgical Planning Laboratory - Brigham & Women's Hospital - Boston, Massachusetts USA - a teaching affiliate of Harvard Medical School

Surgical Planning Laboratory

The Publication Database hosted by SPL

All Publications | Upload | Advanced Search | Gallery View | Download Statistics | Help | Import | Log in

Extended Broca's Area in the Functional Connectome of Language in Adults: Combined Cortical and Subcortical Single-subject Analysis using fMRI and DTI Tractography

Institution:
1Surgical Planning Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. jjlemaire@chu-clermontferrand.fr.
2Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
3Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Publisher:
Springer
Publication Date:
Jul-2013
Journal:
Brain Topogr
Volume Number:
26
Issue Number:
3
Pages:
428-41
Citation:
Brain Topogr. 2013 Jul;26(3):428-41.
PubMed ID:
23001727
PMCID:
PMC3966184
Keywords:
Language, fMRI, DTI, Fiber Tracking, Connectome, Broca's area
Appears in Collections:
NAC, LMI, NA-MIC, NCIGT, SLICER, SPL
Sponsors:
P41 RR019703/RR/NCRR NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
P41 EB015898/EB/NIBIB NIH HHS/United States
P41 RR013218/RR/NCRR NIH HHS/United States
P01 CA067165/CA/NCI NIH HHS/United States
Generated Citation:
Lemaire J-J., Golby A.J., Wells III W.M., Pujol S., Tie Y., Rigolo L., Yarmarkovich A., Pieper S., Westin C-F., Jolesz F.A., Kikinis R. Extended Broca's Area in the Functional Connectome of Language in Adults: Combined Cortical and Subcortical Single-subject Analysis using fMRI and DTI Tractography. Brain Topogr. 2013 Jul;26(3):428-41. PMID: 23001727. PMCID: PMC3966184.
Downloaded: 671 times. [view map]
Paper: Download, View online
Export citation:
Google Scholar: link

Traditional models of the human language circuitry encompass three cortical areas, Broca's, Geschwind's and Wernicke's, and their connectivity through white matter fascicles. The neural connectivity deep to these cortical areas remains poorly understood, as does the macroscopic functional organization of the cortico-subcortical language circuitry. In an effort to expand current knowledge, we combined functional MRI (fMRI) and diffusion tensor imaging to explore subject-specific structural and functional macroscopic connectivity, focusing on Broca's area. Fascicles were studied using diffusion tensor imaging fiber tracking seeded from volumes placed manually within the white matter. White matter fascicles and fMRI-derived clusters (antonym-generation task) of positive and negative blood-oxygen-level-dependent (BOLD) signal were co-registered with 3-D renderings of the brain in 12 healthy subjects. Fascicles connecting BOLD-derived clusters were analyzed within specific cortical areas: Broca's, with the pars triangularis, the pars opercularis, and the pars orbitaris; Geschwind's and Wernicke's; the premotor cortex, the dorsal supplementary motor area, the middle temporal gyrus, the dorsal prefrontal cortex and the frontopolar region. We found a functional connectome divisible into three systems-anterior, superior and inferior-around the insula, more complex than previously thought, particularly with respect to a new extended Broca's area. The extended Broca's area involves two new fascicles: the operculo-premotor fascicle comprised of well-organized U-shaped fibers that connect the pars opercularis with the premotor region; and (2) the triangulo-orbitaris system comprised of intermingled U-shaped fibers that connect the pars triangularis with the pars orbitaris. The findings enhance our understanding of language function.

Additional Material
1 File (169.474kB)
Lamaire-BrainTopogr2013-fig3.jpg (169.474kB)