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Differences in Simple Morphological Variables in Ruptured and Unruptured Middle Cerebral Artery Aneurysms

Institution:
1Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA.
2Harvard Medical School, Boston, MA, USA.
3Department of Neurosurgery, The University of Texas Medical School at Houston, Houston, TX, USA.
4Surgical Planning Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Publication Date:
Nov-2012
Journal:
J Neurosurg
Volume Number:
117
Issue Number:
5
Pages:
913-9
Citation:
J Neurosurg. 2012 Nov;117(5):913-9.
PubMed ID:
22957531
Keywords:
Aneurysm, subarachnoid hemorrhage, epidemiology, unruptured intracranial aneurysm, morphological parameter, cerebral flow dynamics, vascular disorders
Appears in Collections:
SPL, NA-MIC, SLICER
Generated Citation:
Lin N., Ho A., Gross B.A., Pieper S., Frerichs K.U., Day A.L., Du R. Differences in Simple Morphological Variables in Ruptured and Unruptured Middle Cerebral Artery Aneurysms. J Neurosurg. 2012 Nov;117(5):913-9. PMID: 22957531.
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Management of unruptured intracranial aneurysms remains controversial in neurosurgery. The contribution of morphological parameters has not been included in the treatment paradigm in a systematic manner or for any particular aneurysm location. The authors present a large sample of middle cerebral artery (MCA) aneurysms that were assessed using morphological variables to determine the parameters associated with aneurysm rupture. Methods:: Preoperative CT angiography (CTA) studies were evaluated using Slicer software to generate 3D models of the aneurysms and their surrounding vascular architecture. Morphological parameters examined in each model included 5 variables already defined in the literature (aneurysm size, aspect ratio, aneurysm angle, vessel angle, and size ratio) and 3 novel variables (flow angle, distance to the genu, and parent-daughter angle). Univariate and multivariate statistical analyses were performed to determine statistical significance. Results:: Between 2005 and 2008, 132 MCA aneurysms were treated at a single institution, and CTA studies of 79 aneurysms (40 ruptured and 39 unruptured) were analyzed. Fifty-three aneurysms were excluded because of reoperation (4), associated AVM (2), or lack of preoperative CTA studies (47). Ruptured aneurysms were associated with larger size, greater aspect ratio, larger aneurysm and flow angles, and smaller parent-daughter angle. Multivariate logistic regression revealed that aspect ratio, flow angle, and parent-daughter angle were the strongest factors associated with ruptured aneurysms. Conclusions:: Aspect ratio, flow angle, and parent-daughter angle are more strongly associated with ruptured MCA aneurysms than size. The association of parameters independent of aneurysm morphology with ruptured aneurysms suggests that these parameters may be associated with an increased risk of aneurysm rupture. These factors are readily applied in clinical practice and should be considered in addition to aneurysm size when assessing the risk of aneurysm rupture specific to the MCA location.