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Localized Differences in Caudate and Hippocampal Shape are Associated with Schizophrenia but not Antipsychotic Type

Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
Elsevier Science
Publication Date:
Psychiatry Res
Volume Number:
Issue Number:
Psychiatry Res. 2013 Jan 30;211(1):1-10.
PubMed ID:
MRI, Schizophrenia, Morphometry, Caudate, Hippocampus, Antipsychotic
Appears in Collections:
P01 CA142538/CA/NCI NIH HHS/United States
P01 DA022446/DA/NIDA NIH HHS/United States
P01 EB002779/EB/NIBIB NIH HHS/United States
P30 HD003110/HD/NICHD NIH HHS/United States
R01 CA082659/CA/NCI NIH HHS/United States
R01 MH086633/MH/NIMH NIH HHS/United States
R21 AG033387/AG/NIA NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
UL1 RR025747/RR/NCRR NIH HHS/United States
Generated Citation:
McClure R.K., Styner M., Maltbie E., Lieberman J.A., Gouttard S., Gerig G., Shi X., Zhu H. Localized Differences in Caudate and Hippocampal Shape are Associated with Schizophrenia but not Antipsychotic Type. Psychiatry Res. 2013 Jan 30;211(1):1-10. PMID: 23142194. PMCID: PMC3557605.
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BACKGROUND: Caudate and hippocampal volume differences in patients with schizophrenia are associated with disease and antipsychotic treatment, but local shape alterations have not been thoroughly examined. METHODS: Schizophrenia patients randomly assigned to haloperidol and olanzapine treatment underwent MRI scans at 3, 6, and 12 months. The caudate and hippocampus were represented as medial representations (M-reps); mesh structures derived from automatic segmentations of high resolution MRIs. Two quantitative shape measures were examined: local width and local deformation. A novel nonparametric statistical method adjusted exponentially tilted (ET) likelihood, was used to compare the shape measures across the three groups while controlling for covariates. RESULTS: Longitudinal shape change was not observed in the hippocampus or caudate when the treatment groups and controls were examined in a global analysis, nor when the three groups were examined individually. Both baseline and repeated measures analysis showed differences in local caudate and hippocampal size between patients and controls, while no consistent differences were shown between treatment groups. CONCLUSIONS: Regionally specific differences in local hippocampal and caudate shape are present in schizophrenic patients. Treatment related longitudinal shape change was not observed within the studied timeframe. Our results provide additional evidence for disrupted cortico-basal ganglia-thalamo-cortical circuits in schizophrenia. CLINICAL TRIAL INFORMATION: This longitudinal study was conducted from March 1, 1997 to July 31, 2001 at 14 academic medical centers (11 in the United States, one in Canada, one in the Netherlands, and one in England). This study was performed prior to the establishment of centralized registries of federally and privately supported clinical trials.

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