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Towards Fast and Accurate Temperature Mapping with Proton Resonance Frequency-based MR Thermometry

1Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
2Department of Radiology, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA, USA.
Publication Date:
Quant Imaging Med Surg
Volume Number:
Issue Number:
Quant Imaging Med Surg. 2012 Mar;2(1):21-32.
PubMed ID:
Thermometry, focused ultrasound (FUS) thermal therapy, proton resonance frequency (PRF), temperature mapping, pulse sequence, motion
Appears in Collections:
P41 EB015898/EB/NIBIB NIH HHS/United States
P41 RR019703/RR/NCRR NIH HHS/United States
R01 CA149342/CA/NCI NIH HHS/United States
Generated Citation:
Yuan J., Mei C-S., Panych L.P., McDannold N., Madore B. Towards Fast and Accurate Temperature Mapping with Proton Resonance Frequency-based MR Thermometry. Quant Imaging Med Surg. 2012 Mar;2(1):21-32. PMID: 22773966. PMCID: PMC3389756.
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The capability to image temperature is a very attractive feature of MRI and has been actively exploited for guiding minimally-invasive thermal therapies. Among many MR-based temperature-sensitive approaches, proton resonance frequency (PRF) thermometry provides the advantage of excellent linearity of signal with temperature over a large temperature range. Furthermore, the PRF shift has been shown to be fairly independent of tissue type and thermal history. For these reasons, PRF method has evolved into the most widely used MR-based thermometry method. In the present paper, the basic principles of PRF-based temperature mapping will be reviewed, along with associated pulse sequence designs. Technical advancements aimed at increasing the imaging speed and/or temperature accuracy of PRF-based thermometry sequences, such as image acceleration, fat suppression, reduced field-of-view imaging, as well as motion tracking and correction, will be discussed. The development of accurate MR thermometry methods applicable to moving organs with non-negligible fat content represents a very challenging goal, but recent developments suggest that this goal may be achieved. If so, MR-guided thermal therapies may be expected to play an increasingly-important therapeutic and palliative role, as a minimally-invasive alternative to surgery.

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