Surgical Planning Laboratory - Brigham & Women's Hospital - Boston, Massachusetts USA - a teaching affiliate of Harvard Medical School

Surgical Planning Laboratory

The Publication Database hosted by SPL

All Publications | Upload | Advanced Search | Gallery View | Download Statistics | Help | Import | Log in

Estimation of Extracellular Volume from Regularized Multi-shell Diffusion MRI

Institution:
1Laboratory of Mathematical Imaging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
2VA Boston Healthcare System, Brockton, MA, USA.
Publisher:
Int Conf Med Image Comput Comput Assist Interv. MICCAI 2012
Publication Date:
Oct-2012
Journal:
Med Image Comput Comput Assist Interv
Volume Number:
15
Issue Number:
Pt 2
Pages:
305-12
Citation:
Int Conf Med Image Comput Comput Assist Interv. 2012 Oct;15(Pt 2):305-12.
PubMed ID:
23286062
PMCID:
PMC4039075
Appears in Collections:
NAC, LMI, PNL, SLICER, SPL
Sponsors:
P41 EB015902/EB/NIBIB NIH HHS/United States
P41 RR013218/RR/NCRR NIH HHS/United States
R01 MH092862/MH/NIMH NIH HHS/United States
R01 MH074794/MH/NIMH NIH HHS/United States
Generated Citation:
Pasternak O., Shenton M.E., Westin C-F. Estimation of Extracellular Volume from Regularized Multi-shell Diffusion MRI. Int Conf Med Image Comput Comput Assist Interv. 2012 Oct;15(Pt 2):305-12. PMID: 23286062. PMCID: PMC4039075.
Downloaded: 910 times. [view map]
Paper: Download, View online
Export citation:
Google Scholar: link

Diffusion MRI measures micron scale displacement of water molecules, providing unique insight into microstructural tissue architecture. However, current practical image resolution is in the millimeter scale, and thus diffusivities from many tissue compartments are averaged in each voxel, reducing the sensitivity and specificity of the measurement to subtle pathologies. Recent studies have pointed out that eliminating the contribution of extracellular water increases the sensitivity of the diffusion measures to tissue architecture. Moreover, in brain imaging, estimation of the extracellular volume appears to indicate pathological processes such as atrophy, edema and neuroinflammation. Here we study the free-water method, which assumes a bi-tensor model. We add low b-value shells to a regular DTI acquisition and present methods to improve the estimation of the model parameters using the extra information. In addition, we define a Laplace-Beltrami regularization operator that further stabilizes the multi-shell estimation.

Additional Material
1 File (146.992kB)
Pasternak-MICCAI2012-fig2.jpg (146.992kB)