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Lung Volumes and Emphysema in Smokers with Interstitial Lung Abnormalities

Pulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Publication Date:
N Engl J Med
Volume Number:
Issue Number:
N Engl J Med. 2011 Mar 10;364(10):897-906.
PubMed ID:
Appears in Collections:
K08 HL092222/HL/NHLBI NIH HHS/United States
K23 HL087030/HL/NHLBI NIH HHS/United States
K23 HL089353/HL/NHLBI NIH HHS/United States
K25 HL104085/HL/NHLBI NIH HHS/United States
R01 HL111024/HL/NHLBI NIH HHS/United States
R21 CA116271/CA/NCI NIH HHS/United States
T32 HL007427/HL/NHLBI NIH HHS/United States
U01 HL089856/HL/NHLBI NIH HHS/United States
U01 HL089897/HL/NHLBI NIH HHS/United States
Generated Citation:
Washko G.R., Hunninghake G.M., Fernández I.E., Nishino M., Okajima Y., Yamashiro T., Ross J.C., San Jose Estepar R., Lynch D.A., Brehm J.M., Andriole K.P., Diaz A.A., Khorasani R., D'Aco K., Sciurba F.C., Silverman E.K., Hatabu H., Rosas I.O. Lung Volumes and Emphysema in Smokers with Interstitial Lung Abnormalities. N Engl J Med. 2011 Mar 10;364(10):897-906. PMID: 21388308. PMCID: PMC3074462.
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Cigarette smoking is associated with emphysema and radiographic interstitial lung abnormalities. The degree to which interstitial lung abnormalities are associated with reduced total lung capacity and the extent of emphysema is not known. We looked for interstitial lung abnormalities in 2416 (96%) of 2508 high-resolution computed tomographic (HRCT) scans of the lung obtained from a cohort of smokers. We used linear and logistic regression to evaluate the associations between interstitial lung abnormalities and HRCT measurements of total lung capacity and emphysema.

Additional Material
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Washko-NEJM2011-fig1.jpg (155.447kB)