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Associations between White Matter Microstructure and Infants' Working Memory

Institution:
1Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA. sjshort@med.unc.edu
2Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC, USA.
3Department of Psychology, University of North Carolina, Chapel Hill, NC, USA.
4Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA.
5Department of Radiology, University of North Carolina, Chapel Hill, NC, USA.
6Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, USA.
Publisher:
Elsevier Science
Publication Date:
Jan-2013
Journal:
Neuroimage
Volume Number:
64
Pages:
156-66
Citation:
Neuroimage. 2013 Jan 1;64:156-66.
Links:
http://dx.doi.org/10.1016/j.neuroimage.2012.09.021
PubMed ID:
22989623
PMCID:
PMC3838303
Keywords:
infant, working memory, white matter, diffusion tensor imaging, Brain Development
Appears in Collections:
NA-MIC, SLICER
Sponsors:
P30 HD003110/HD/NICHD NIH HHS/United States
P50 MH064065/MH/NIMH NIH HHS/United States
R01 HD053000/HD/NICHD NIH HHS/United States
R01 MH070890/MH/NIMH NIH HHS/United States
R01 MH091645/MH/NIMH NIH HHS/United States
T32 HD007376/HD/NICHD NIH HHS/United States
T32 HD040127/HD/NICHD NIH HHS/United States
T32 NS007431/NS/NINDS NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Short S.J., Elison J.T., Goldman B.D., Styner M., Gu H., Connelly M., Maltbie E., Woolson S., Lin W., Gerig G., Reznick J.S., Gilmore J.H. Associations between White Matter Microstructure and Infants' Working Memory. Neuroimage. 2013 Jan 1;64:156-66. PMID: 22989623. PMCID: PMC3838303.
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Working memory emerges in infancy and plays a privileged role in subsequent adaptive cognitive development. The neural networks important for the development of working memory during infancy remain unknown. We used diffusion tensor imaging (DTI) and deterministic fiber tracking to characterize the microstructure of white matter fiber bundles hypothesized to support working memory in 12-month-old infants (n=73). Here we show robust associations between infants' visuospatial working memory performance and microstructural characteristics of widespread white matter. Significant associations were found for white matter tracts that connect brain regions known to support working memory in older children and adults (genu, anterior and superior thalamic radiations, anterior cingulum, arcuate fasciculus, and the temporal-parietal segment). Better working memory scores were associated with higher FA and lower RD values in these selected white matter tracts. These tract-specific brain-behavior relationships accounted for a significant amount of individual variation above and beyond infants' gestational age and developmental level, as measured with the Mullen Scales of Early Learning. Working memory was not associated with global measures of brain volume, as expected, and few associations were found between working memory and control white matter tracts. To our knowledge, this study is among the first demonstrations of brain-behavior associations in infants using quantitative tractography. The ability to characterize subtle individual differences in infant brain development associated with complex cognitive functions holds promise for improving our understanding of normative development, biomarkers of risk, experience-dependent learning and neuro-cognitive periods of developmental plasticity.

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