Surgical Planning Laboratory - Brigham & Women's Hospital - Boston, Massachusetts USA - a teaching affiliate of Harvard Medical School

Surgical Planning Laboratory

The Publication Database hosted by SPL

All Publications | Upload | Advanced Search | Gallery View | Download Statistics | Help | Import | Log in

Abnormalities of Middle Longitudinal Fascicle and Disorganization in Patients with Schizophrenia

1Laboratory of Neuroscience, Clinical Neuroscience Division, Department of Psychiatry, Boston Veterans Affairs Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA, USA.
2Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
3Center for Morphometric Analysis, Athinoula A. Martinos Center for Biomedical Imaging, Departments of Psychiatry, Neurology and Radiology Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Elsevier Science
Publication Date:
Schizophr Res
Volume Number:
Issue Number:
Schizophr Res. 2013 Feb;143(2-3):253-9.
PubMed ID:
Schizophrenia, DTI, FA, Middle longitudinal fascicle, Disorganization, Attention Deficit
Appears in Collections:
K05 MH070047/MH/NIMH NIH HHS/United States
P50 MH080272/MH/NIMH NIH HHS/United States
R01 MH040799/MH/NIMH NIH HHS/United States
R01 MH050740/MH/NIMH NIH HHS/United States
R01 MH074794/MH/NIMH NIH HHS/United States
R01 DA027804/DA/NIDA NIH HHS/United States
R21 MH084041/MH/NIMH NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Asami T., Saito Y., Whitford T.J., Makris N., Niznikiewicz M.A., McCarley R.W., Shenton M.E., Kubicki M. Abnormalities of Middle Longitudinal Fascicle and Disorganization in Patients with Schizophrenia. Schizophr Res. 2013 Feb;143(2-3):253-9. PMID: 23290607. PMCID: PMC3587354.
Downloaded: 973 times. [view map]
Paper: Download, View online
Export citation:
Google Scholar: link

The middle longitudinal fascicle (MdLF) is a long association fiber connecting the superior temporal gyrus (STG) and temporal pole with the angular gyrus through the white matter of the STG, structures which are known to play a crucial role in the pathology of schizophrenia. Functions of MdLF are thought to be related to language and thought processing in the left hemisphere, and with attention in the right hemisphere. While deficits of these functions are core clinical features of schizophrenia, no study has investigated the structural abnormalities of MdLF in schizophrenia. METHOD: 3T diffusion tensor data was acquired from twenty-six patients with schizophrenia and twenty-five healthy control subjects. Streamline tractography technique was used to extract MdLF. Fractional anisotropy (FA) was compared between the two groups. In addition, relationships were investigated between FA in the left MdLF and the Disorganized Thoughts Factor derived from the Positive and Negative Symptom Scale five factor model, and between FA in the right MdLF and the Poor Attention. RESULT: Relative to control subjects, the patients with chronic schizophrenia showed significant mean FA reductions in the bilateral MdLF. The FA of the left MdLF demonstrated a significant negative association with the Disorganized Thoughts Factor, and the FA of the right MdLF showed a significant negative relationship with the Poor Attention. CONCLUSIONS: This study provides new evidence for structural deficits in the bilateral MdLF in patients with chronic schizophrenia. It further demonstrates the contribution of these abnormalities to the core clinical features - especially to disorganization and attention deficit.

Additional Material
1 File (47.85kB)
Asami-SchizophrRes2013-fig1.jpg (47.85kB)