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Diffusion Tensor Imaging-based Characterization of Brain Neurodevelopment in Primates

Institution:
1Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA. yundiuu@gmail.com
2Department of Computer Science, University of North Carolina, Chapel Hill, NC, USA.
3Department of Psychology, Harlow Center, University of Wisconsin, Madison, WI, USA.
4Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA.
Publisher:
HighWire
Publication Date:
Jan-2013
Journal:
Cereb Cortex
Volume Number:
23
Issue Number:
1
Pages:
36-48
Citation:
Cereb Cortex. 2013 Jan;23(1):36-48.
Links:
http://dx.doi.org/10.1093/cercor/bhr372
PubMed ID:
22275483
PMCID:
PMC3513950
Keywords:
Atlas, Brain Development, diffusion tensor imaging, rhesus, tractography
Appears in Collections:
NA-MIC, SLICER
Sponsors:
K01 MH083045/MH/NIMH NIH HHS/United States
P01 CA142538/CA/NCI NIH HHS/United States
P01 DA022446/DA/NIDA NIH HHS/United States
P01 HD039386/HD/NICHD NIH HHS/United States
P30 HD003110/HD/NICHD NIH HHS/United States
P50 MH064065/MH/NIMH NIH HHS/United States
P50 MH078105/MH/NIMH NIH HHS/United States
R01 AI067518/AI/NIAID NIH HHS/United States
R01 HD053000/HD/NICHD NIH HHS/United States
R01 MH086633/MH/NIMH NIH HHS/United States
R01 MH091645/MH/NIMH NIH HHS/United States
R21 AG033387/AG/NIA NIH HHS/United States
T32 HD040127/HD/NICHD NIH HHS/United States
T32 MH019111/MH/NIMH NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
UL1 RR025747/RR/NCRR NIH HHS/United States
Generated Citation:
Shi Y., Short S.J., Knickmeyer R.C., Wang J., Coe C.L., Niethammer M., Gilmore J.H., Zhu H., Styner M. Diffusion Tensor Imaging-based Characterization of Brain Neurodevelopment in Primates. Cereb Cortex. 2013 Jan;23(1):36-48. PMID: 22275483. PMCID: PMC3513950.
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Primate neuroimaging provides a critical opportunity for understanding neurodevelopment. Yet the lack of a normative description has limited the direct comparison with changes in humans. This paper presents for the first time a cross-sectional diffusion tensor imaging (DTI) study characterizing primate brain neurodevelopment between 1 and 6 years of age on 25 healthy undisturbed rhesus monkeys (14 male, 11 female). A comprehensive analysis including region-of-interest, voxel-wise, and fiber tract-based approach demonstrated significant changes of DTI properties over time. Changes in fractional anisotropy (FA), mean diffusivity, axial diffusivity (AD), and radial diffusivity (RD) exhibited a heterogeneous pattern across different regions as well as along fiber tracts. Most of these patterns are similar to those from human studies yet a few followed unique patterns. Overall, we observed substantial increase in FA and AD and a decrease in RD for white matter (WM) along with similar yet smaller changes in gray matter (GM). We further observed an overall posterior-to-anterior trend in DTI property changes over time and strong correlations between WM and GM development. These DTI trends provide crucial insights into underlying age-related biological maturation, including myelination, axonal density changes, fiber tract reorganization, and synaptic pruning processes.

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