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Labeled Needle Rendering Solution for Image Guided Brachytherapy

1Technische Universität, München, Germany.
2Surgical Planning Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Technische Universität, München
Publication Date:
Master's Thesis, Technische Universität, München, Germany, 2012 Dec;
Image guided therapy, Interstitial Gynecological Brachytherapy, needle labelling, needle rendering in MR images, 3D Slicer, iGyne
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Pernelle G. Labeled Needle Rendering Solution for Image Guided Brachytherapy. Master's Thesis, Technische Universität, München, Germany, 2012 Dec;
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There is increasing evidence of the value of using medical imagery to guide therapy of various types of malignancies. This thesis focuses on image analysis techniques to support therapy of gynecologic cancer. Gynecologic cancers involve malignancies of the uterus, cervix, vagina/vulva, and the ovaries. Treatment of gynecologic cancers typically involves radiation therapy in two steps: first external beam radiation, and then brachytherapy in which applicators are used to place radiation isotopes directly in the tumor. Magnetic resonance imagery is widely used worldwide to diagnose gynecological cancers, and is in the early stages of being used also for placement of applicators and treatment planning. The contribution of this thesis is in the area of image analysis techniques for registration and segmentation of image-guided gynecological cancer therapy. Two computational algorithms have been introduced in this thesis: registration of the applicator, and extraction of the needles. This work has been released for public use in a new open-source software module that integrates efficiently with clinical workflow. All methods are described in details in this thesis and are evaluated with phantom and real patient data from cases performed in the Advanced Modality Image-Guided Operating (AMIGO) suite of the Brigham and Women’s Hospital.

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