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Neuroimaging of Structural Pathology and Connectomics in Traumatic Brain Injury: Toward Personalized Outcome Prediction

1Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, CA, USA.
2Scientific Computing Institute, University of Utah, Salt Lake City, UT, USA.
3Kitware, Inc., Clifton Park, NY, USA.
4Brain Injury Research Center, Department of Neurosurgery, University of California, Los Angeles, CA, USA.
5Surgical Planning Laboratory, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Publication Date:
NeuroImage: Clinical
Volume Number:
Issue Number:
Neuroimage Clin. 2012 Aug 24;1(1):1-17.
PubMed ID:
Trauma, Neuroimaging, MRI/fMRI, Diffusion Tensor, Outcome measures
Appears in Collections:
U54 EB005149/EB/NIBIB NIH HHS/United States
P01 NS058489/NS/NINDS NIH HHS/United States
P41 EB015902/EB/NIBIB NIH HHS/United States
Generated Citation:
Irimia A., Wang B., Aylward S.R., Prastawa M.W., Pace D.F., Gerig G., Hovda D.A., Kikinis R., Vespa P.M., Van Horn J.D. Neuroimaging of Structural Pathology and Connectomics in Traumatic Brain Injury: Toward Personalized Outcome Prediction. Neuroimage Clin. 2012 Aug 24;1(1):1-17. PMID: 24179732. PMCID: PMC3757727.
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Recent contributions to the body of knowledge on traumatic brain injury (TBI) favor the view that multimodal neuroimaging using structural and functional magnetic resonance imaging (MRI and fMRI, respectively) as well as diffusion tensor imaging (DTI) has excellent potential to identify novel biomarkers and predictors of TBI outcome. This is particularly the case when such methods are appropriately combined with volumetric/morphometric analysis of brain structures and with the exploration of TBI-related changes in brain network properties at the level of the connectome. In this context, our present review summarizes recent developments on the roles of these two techniques in the search for novel structural neuroimaging biomarkers that have TBI outcome prognostication value. The themes being explored cover notable trends in this area of research, including (1) the role of advanced MRI processing methods in the analysis of structural pathology, (2) the use of brain connectomics and network analysis to identify outcome biomarkers, and (3) the application of multivariate statistics to predict outcome using neuroimaging metrics. The goal of the review is to draw the community's attention to these recent advances on TBI outcome prediction methods and to encourage the development of new methodologies whereby structural neuroimaging can be used to identify biomarkers of TBI outcome.

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