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Alteration to Hippocampal Shape in Cannabis Users with and without Schizophrenia

School of Psychology, University of Wollongong, Wollongong, NSW, Australia.
Publication Date:
Schizophr Res
Volume Number:
Issue Number:
Schizophr Res. 2013 Jan;143(1):179-84.
PubMed ID:
Cannabis, Schizophrenia, Hippocampus, Shape analysis, Neuroimaging
Appears in Collections:
Australian Research Council Future Fellowship, FT110100752
NHMRC Senior Principal Research Fellowship 628386 and Program Grant 566529
NHMRC Fellowship Award 1001973
NHMRC Career Development Fellowship 1007716
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Solowij N., Walterfang M., Lubman D.I., Whittle S., Lorenzetti V., Styner M., Velakoulis D., Pantelis C., Yücel M. Alteration to Hippocampal Shape in Cannabis Users with and without Schizophrenia. Schizophr Res. 2013 Jan;143(1):179-84. PMID: 23201308.
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Abnormalities in hippocampal morphology are characteristic of schizophrenia and have also been reported in chronic cannabis users. There is a paucity of research investigating potential additive effects of cannabis use on brain pathology associated with schizophrenia. In this study, we performed hippocampal shape analysis in cannabis-using and non-using patients with schizophrenia, healthy cannabis users and healthy non-using controls. Hippocampal shape changes were observed in each group relative to controls, with the greatest degree of alterations (i.e., deflations across the hippocampus, and with an anterior predisposition), in cannabis-using schizophrenia patients. These alterations were associated with cannabis use patterns and psychotic symptoms.

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