Surgical Planning Laboratory - Brigham & Women's Hospital - Boston, Massachusetts USA - a teaching affiliate of Harvard Medical School

Surgical Planning Laboratory

The Publication Database hosted by SPL

All Publications | Upload | Advanced Search | Gallery View | Download Statistics | Help | Import | Log in

Regionally Selective Atrophy of Subcortical Structures in Prodromal HD as Revealed by Statistical Shape Analysis

Institution:
1Center for Imaging Science, Institute for Computational Medicine and Department of Applied Mathematics and Statistics, Johns Hopkins University, WSE, Baltimore, MD, USA.
2Center for Imaging Science, Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, WSE, Baltimore, MD, USA.
3Center for Imaging Science, Johns Hopkins University, WSE, Baltimore, MD, USA.
4University of Washington, Department of Radiology, Seattle Children's Research Institute, Seattle, WA, USA.
5Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, IA, USA.
6Departments of Psychiatry and Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
7Department of Neurology, University of Michigan, and VAAAHS Geriatrics Research, Education, and Clinical Center, Ann Arbor, MI, USA.
8Center for Imaging Science, Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, WSE, Baltimore, MD, USA.
9Division of Neurobiology, Departments of Psychiatry, Neurology, Neuroscience and Pharmacology, and Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Publisher:
John Wiley & Sons, Inc.
Publication Date:
Mar-2014
Journal:
Hum Brain Mapp
Volume Number:
35
Issue Number:
3
Pages:
792-809
Citation:
Hum Brain Mapp. 2014 Mar;35(3):792-809.
PubMed ID:
23281100
PMCID:
PMC3715588
Keywords:
Striatal Atrophy, surface-based morphometry, Pallidus Atrophy, diffeomorphic mapping, surface registration
Appears in Collections:
NA-MIC
Sponsors:
P41 EB015909/EB/NIBIB NIH HHS/United States
P41 RR015241/RR/NCRR NIH HHS/United States
R01 EB000975/EB/NIBIB NIH HHS/United States
R01 EB008171/EB/NIBIB NIH HHS/United States
R01 NS040068/NS/NINDS NIH HHS/United States
R01 NS050568/NS/NINDS NIH HHS/United States
R01 NS054893/NS/NINDS NIH HHS/United States
S10 RR023392/RR/NCRR NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Younes L., Ratnanather J.T., Brown T., Aylward E., Nopoulos P., Johnson H., Magnotta V.A., Paulsen J.S., Margolis R.L., Albin R.L., Miller M.I., Ross C.A. Regionally Selective Atrophy of Subcortical Structures in Prodromal HD as Revealed by Statistical Shape Analysis. Hum Brain Mapp. 2014 Mar;35(3):792-809. PMID: 23281100. PMCID: PMC3715588.
Downloaded: 801 times. [view map]
Paper: Download, View online
Export citation:
Google Scholar: link

Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through "Large Deformation Diffeomorphic Metric Mapping" of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease. On the basis of the relation to cortico-basal ganglia circuitry, we propose that statistical shape analysis, along with other structural and functional imaging studies, may help expand our understanding of the brain circuitry affected and other aspects of the neurobiology of HD, and also guide the most effective strategies for intervention.

Additional Material
1 File (190.01kB)
Younes-HumBrainMapp2014-fig1.jpg (190.01kB)