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Human Middle Longitudinal Fascicle: Segregation and Behavioral-clinical Implications of Two Distinct Fiber Connections Linking Temporal Pole and Superior Temporal Gyrus with the Angular Gyrus or Superior Parietal Lobule using Multi-Tensor Tractography

Institution:
1Departments of Psychiatry and Neurology Services, Center for Neural Systems Investigations, Center for Morphometric Analysis, Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, USA. nikos@cma.mgh.harvard.edu.
2Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, USA.
3Department of Electronics, Information, and Bioengineering, Politecnico di Milano, Milano, Italy.
Publisher:
Springer
Publication Date:
Sep-2013
Journal:
Brain Imaging Behav
Volume Number:
7
Issue Number:
3
Pages:
335-52
Citation:
Brain Imaging Behav. 2013 Sep;7(3):335-52.
PubMed ID:
23686576
PMCID:
PMC3830590
Keywords:
High-angular resolution diffusion imaging, Middle longitudinal fascicle, Middle longitudinal fasciculus, Angular gyrus, Superior parietal lobule, Primary progressive aphasia, Neurodegenerative disorders
Appears in Collections:
PNL, SLICER, SPL
Sponsors:
R01 DA027804/DA/NIDA NIH HHS/United States
K05 MH070047/MH/NIMH NIH HHS/United States
P50 MH080272/MH/NIMH NIH HHS/United States
R01 DA027804/DA/NIDA NIH HHS/United States
R01 M0074794/PHS HHS/United States
R01 MH050740/MH/NIMH NIH HHS/United States
R01 MH074794/MH/NIMH NIH HHS/United States
R01 MH097979/MH/NIMH NIH HHS/United States
R21 NS077059/NS/NINDS NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Makris N., Preti M.G., Wassermann D., Rathi Y., Papadimitriou G.M., Yergatian C., Dickerson B.C., Shenton M.E., Kubicki M. Human Middle Longitudinal Fascicle: Segregation and Behavioral-clinical Implications of Two Distinct Fiber Connections Linking Temporal Pole and Superior Temporal Gyrus with the Angular Gyrus or Superior Parietal Lobule using Multi-Tensor Tractography. Brain Imaging Behav. 2013 Sep;7(3):335-52. PMID: 23686576. PMCID: PMC3830590.
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The middle longitudinal fascicle (MdLF) is a major fiber connection running principally between the superior temporal gyrus and the parietal lobe, neocortical regions of great biological and clinical interest. Although one of the most prominent cerebral association fiber tracts, it has only recently been discovered in humans. In this high angular resolution diffusion imaging (HARDI) MRI study, we delineated the two major fiber connections of the human MdLF, by examining morphology, topography, cortical connections, biophysical measures, volume and length in seventy-four brains. These two fiber connections course together through the dorsal temporal pole and the superior temporal gyrus maintaining a characteristic topographic relationship in the mediolateral and ventrodorsal dimensions. As these pathways course towards the parietal lobe, they split to form separate fiber pathways, one following a ventrolateral trajectory and connecting with the angular gyrus and the other following a dorsomedial route and connecting with the superior parietal lobule. Based on the functions of their cortical affiliations, we suggest that the superior temporal-angular connection of the MdLF, i.e., STG(MdLF)AG plays a role in language and attention, whereas the superior temporal-superior parietal connection of the MdLF, i.e., STG(MdLF)SPL is involved in visuospatial and integrative audiovisual functions. Furthermore, the MdLF may have clinical implications in neurodegenerative disorders such as primary progressive aphasia, frontotemporal dementia, posterior cortical atrophy, corticobulbar degeneration and Alzheimer's disease as well as attention-deficit/hyperactivity disorder and schizophrenia.

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