Surgical Planning Laboratory - Brigham & Women's Hospital - Boston, Massachusetts USA - a teaching affiliate of Harvard Medical School

Surgical Planning Laboratory

The Publication Database hosted by SPL

All Publications | Upload | Advanced Search | Gallery View | Download Statistics | Help | Import | Log in

White Matter Microstructure in Individuals at Clinical High Risk of Psychosis: A Whole-Brain Diffusion Tensor Imaging Study

Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA;
Publication Date:
Schizophr Bull
Volume Number:
Issue Number:
Schizophr Bull. 2014 Jul;40(4):895-903.
PubMed ID:
TBSS, Diffusivity, mean, parietal lobe, prodrome, radial, Schizophrenia
Appears in Collections:
P51 RR000168/RR/NCRR NIH HHS/United States
Generated Citation:
Clemm von Hohenberg C., Pasternak O., Kubicki M., Ballinger T., Vu M-A., Swisher T., Green K., Giwerc M., Dahlben B., Goldstein J.M., Woo T-U.W., Petryshen T.L., Mesholam-Gately R.I., Woodberry K.A., Thermenos H.W., Mulert C., McCarley R.W., Seidman L.J., Shenton M.E. White Matter Microstructure in Individuals at Clinical High Risk of Psychosis: A Whole-Brain Diffusion Tensor Imaging Study. Schizophr Bull. 2014 Jul;40(4):895-903. PMID: 23737549. PMCID: PMC4059424.
Downloaded: 705 times. [view map]
Paper: Download, View online
Export citation:
Google Scholar: link

Background: The study of individuals at clinical high risk (CHR) for psychosis provides an important opportunity for unraveling pathological mechanisms underlying schizophrenia and related disorders. A small number of diffusion tensor magnetic resonance imaging (DTI) studies in CHR samples have yielded anatomically inconsistent results. The present study is the first to apply tract-based spatial statistics (TBSS) to perform a whole-brain DTI analysis in CHR subjects. Methods: A total of 28 individuals meeting CHR criteria and 34 healthy controls underwent DTI. TBSS was used for a group comparison of fractional anisotropy (FA), as well as axial, radial, and mean diffusivity (AD, RD, and MD). Conversion to psychosis was monitored during a mean follow-up period of 12.3 months. Results: The rate of conversion to psychosis was relatively low (4%). TBSS revealed increased MD in several clusters in the right hemisphere, most notably in the superior longitudinal fasciculus (SLF), posterior corona radiata, and corpus callosum (splenium and body). Increased RD was restricted to a smaller area in the posterior parietal lobe. Conclusion: We present further evidence that white matter microstructure is abnormal in CHR individuals, even in a sample in which the vast majority do not transition to psychosis over the following year. In accord with previous studies on CHR individuals and patients with early-onset schizophrenia, our findings suggest an important pathological role for the parietal lobe and especially the SLF. The latter is known to undergo particularly dynamic microstructural changes during adolescence and early adulthood, a critical phase for the development of psychotic illness.

Additional Material
1 File (413.758kB)
vonHohenberg-SchizophrBull2014-fig1.jpg (413.758kB)