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Localizing the Human Primary Auditory Cortex in vivo using Structural MRI

Institution:
1Special-Lab Non-Invasive Brain Imaging, Leibniz-Institute for Neurobiology Magdeburg, Germany.
2Athinoula A Martinos Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Publisher:
Elsevier Science
Publication Date:
Jun-2014
Journal:
Neuroimage
Volume Number:
93
Issue Number:
Pt 2
Pages:
237-51
Citation:
Neuroimage. 2014 Jun;93(Pt 2):237-51.
PubMed ID:
23891882
PMCID:
PMC3902056
Keywords:
Human Primary Auditory Cortex, In vivo, Localization, MRI
Appears in Collections:
NA-MIC
Sponsors:
P41 RR006009/RR/NCRR NIH HHS/United States
P41 RR014075/RR/NCRR NIH HHS/United States
R01 EB006758/EB/NIBIB NIH HHS/United States
R01 NS052585/NS/NINDS NIH HHS/United States
R01 NS070963/NS/NINDS NIH HHS/United States
R01 RR016594/RR/NCRR NIH HHS/United States
R21 NS072652/NS/NINDS NIH HHS/United States
S10 RR019307/RR/NCRR NIH HHS/United States
S10 RR023401/RR/NCRR NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Wasserthal C., Brechmann A., Stadler J., Fischl B., Engel K. Localizing the Human Primary Auditory Cortex in vivo using Structural MRI. Neuroimage. 2014 Jun;93(Pt 2):237-51. PMID: 23891882. PMCID: PMC3902056.
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Currently there are no routine methods to delineate the primary auditory cortex (PAC) of humans in vivo. Due to the large differences in the location of the PAC between subjects, labels derived from post-mortem brains may be inaccurate when applied to different samples of in vivo brains. Recent magnetic resonance (MR) imaging studies suggested that MR-tissue properties can be used to define the location of the PAC region in vivo. The basis for such an approach is that the PAC region is more strongly myelinated than the secondary areas. We developed a fully automatic method to identify the PAC in conventional anatomical data using a combination of two complementary MR contrasts, i.e., T1 and T2, at 3T with 0.7mm isotropic resolution. Our algorithm maps the anatomical MR data to reconstructed cortical surfaces and uses a classification approach to create an artificial contrast that is highly sensitive to the effects of an increased myelination of the cortex. Consistent with the location of the PAC defined in post-mortem brains, we found a compact region on the medial two thirds of Heschl's gyrus in both hemispheres of all 39 subjects. With further improvements in signal-to-noise ratio of the anatomical data and manual correction of segmentation errors, the results suggest that the primary auditory cortex can be defined in the living brain of single subjects.

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