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Changes of MR and DTI Appearance in Early Human Brain Development

Institution:
1Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
2Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, USA.
Publication Date:
Mar-2010
Journal:
Proc Soc Photo Opt Instrum Eng
Volume Number:
7623
Citation:
Proc Soc Photo Opt Instrum Eng. 2010 Mar 12;7623.
PubMed ID:
24353378
PMCID:
PMC3864971
Appears in Collections:
NA-MIC, SLICER
Sponsors:
U54 EB005149/EB/NIBIB NIH HHS/United States
P50 MH064065/MH/NIMH NIH HHS/United States
P30 HD003110/HD/NICHD NIH HHS/United States
R01 HD055741/HD/NICHD NIH HHS/United States
Generated Citation:
Marc C., Vachet C., Gerig G., Blocher J., Gilmore J., Styner M. Changes of MR and DTI Appearance in Early Human Brain Development. Proc Soc Photo Opt Instrum Eng. 2010 Mar 12;7623. PMID: 24353378. PMCID: PMC3864971.
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Understanding myelination in early brain development is of clinical importance, as many neurological disorders have their origin in early cerebral organization and maturation. The goal of this work is to study a large neonate database acquired with standard MR imagery to illuminate effects of early development in MRI. 90 neonates were selected from a study of healthy brain development. Subjects were imaged via MRI postnatally. MR acquisition included high-resolution structural and diffusion tensor images. Unbiased atlases for structural and DTI data were generated and co-registered into a single coordinate frame for voxel-wise comparison of MR and DTI appearance across time. All original datasets were mapped into this frame and structural image data was additionally intensity normalized. In addition, myelinated white matter probabilistic segmentations from our neonate tissue segmentation were mapped into the same space to study how our segmentation results were affected by the changing intensity characteristics in early development Linear regression maps and p-value maps were computed and visualized. The resulting visualization of voxels-wise corresponding maps of all MR and DTI properties captures early development information in MR imagery. Surprisingly, we encountered regions of seemingly decreased myelinated WM probability over time even though we expected a confident increase for all of the brain. The intensity changes in the MR images in those regions help explain this counterintuitive result. The regressional results indicate that this is an effect of intensity changes due not solely to myelination processes but also likely brain dehydration processes in early postnatal development.

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