Surgical Planning Laboratory - Brigham & Women's Hospital - Boston, Massachusetts USA - a teaching affiliate of Harvard Medical School

Surgical Planning Laboratory

The Publication Database hosted by SPL

All Publications | Upload | Advanced Search | Gallery View | Download Statistics | Help | Import | Log in

Cerebral White Matter Abnormalities and their Associations with Negative but not Positive Symptoms of Schizophrenia

1Laboratory of Neuroscience, Clinical Neuroscience Division, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA, USA.
2Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women׳s Hospital, Harvard Medical School, Boston, MA, USA.
Elsevier Science
Publication Date:
Psychiatry Res
Volume Number:
Issue Number:
Psychiatry Res. 2014 Apr 30;222(1-2):52-9.
PubMed ID:
DTI, FA, Frontal Lobe, Negative symptom, Schizophrenia, TBSS
Appears in Collections:
K05 MH070047/MH/NIMH NIH HHS/United States
P41 EB015902/EB/NIBIB NIH HHS/United States
P41 RR013218/RR/NCRR NIH HHS/United States
P50 MH080272/MH/NIMH NIH HHS/United States
R01 MH074794/MH/NIMH NIH HHS/United States
R01 MH102377/MH/NIMH NIH HHS/United States
R01 MH040799/MH/NIMH NIH HHS/United States
R01 MH050740/MH/NIMH NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Asami T., Hyuk Lee S., Bouix S., Rathi Y., Whitford T.J., Niznikiewicz M., Nestor P.G., McCarley R.W., Shenton M.E., Kubicki M. Cerebral White Matter Abnormalities and their Associations with Negative but not Positive Symptoms of Schizophrenia. Psychiatry Res. 2014 Apr 30;222(1-2):52-9. PMID: 24650453. PMCID: PMC4083818.
Downloaded: 866 times. [view map]
Paper: Download, View online
Export citation:
Google Scholar: link

Although diffusion tensor imaging (DTI) studies have reported fractional anisotropy (FA) abnormalities in multiple white matter (WM) regions in schizophrenia, relationship between abnormal FA and negative symptoms has not been fully explored. DTI data were acquired from twenty-four patients with chronic schizophrenia and twenty-five healthy controls. Regional brain abnormalities were evaluated by conducting FA comparisons in the cerebral and each lobar WMs between groups. Focal abnormalities were also evaluated with a voxel-wise tract specific method. Associations between structural WM changes and negative symptoms were assessed using the Scale for the Assessment of Negative Symptoms (SANS). The patient group showed decreased FA in the cerebrum, especially in the frontal lobe, compared with controls. A voxel-wise analysis showed FA decreases in almost all WM tracts in schizophrenia. Correlation analyses demonstrated negative relationships between FA in the cerebrum, particularly in the left hemisphere, and SANS global and global rating scores (Anhedonia-Asociality, Attention, and Affective-Flattening), and also associations between FA of left frontal lobe and SANS global score, Anhedonia-Asociality, and Attention. This study demonstrates that patients with chronic schizophrenia evince widespread cerebral FA abnormalities and that these abnormalities, especially in the left hemisphere, are associated with negative symptoms.

Additional Material
1 File (211.517kB)
Asami-PsychiatryRes2014-fig1.jpg (211.517kB)