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Localized Abnormalities in the Cingulum Bundle in Patients with Schizophrenia: A Diffusion Tensor Tractography Study

Institution:
1School of Psychology, University of New South Wales, Sydney, NSW, Australia.
2Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
3Laboratory of Mathematics in Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
4Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston Veterans Affairs Healthcare System, Brockton Division, Brockton, MA, USA and Harvard Medical School, Boston, MA, USA.
Publisher:
Elsevier Science
Publication Date:
Jun-2014
Volume Number:
5
Pages:
93-9
Citation:
Neuroimage Clin. 2014 Jun 17;5:93-9.
PubMed ID:
25003032
PMCID:
PMC4081981
Keywords:
Schizophrenia, Cingulum bundle, Cingulate gyrus, Diffusion Tensor Imaging, DTI, Fractional Anisotropy
Appears in Collections:
PNL, LMI, NA-MIC, SLICER, SPL
Sponsors:
Overseas-Based Biomedical Training Fellowship from the National Health and Medical Research Council of Australia NHMRC 520627
R01 MH074794/MH/NIMH NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
K05 MH070047/MH/NIMH NIH HHS/United States
R01 MH050747/MH/NIMH NIH HHS/United States
P50 MH080272/MH/NIMH NIH HHS/United States
R01 MH040799/MH/NIMH NIH HHS/United States
P50 MH080272/MH/NIMH NIH HHS/United States
Generated Citation:
Whitford T.J., Lee S.W., Oh J.S., de Luis-Garcia R., Savadjiev P., Alvarado J.L., Westin C-F., Niznikiewicz M., Nestor P.G., McCarley R.W., Kubicki M., Shenton M.E. Localized Abnormalities in the Cingulum Bundle in Patients with Schizophrenia: A Diffusion Tensor Tractography Study. Neuroimage Clin. 2014 Jun 17;5:93-9. PMID: 25003032. PMCID: PMC4081981.
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The cingulum bundle (CB) connects gray matter structures of the limbic system and as such has been implicated in the etiology of schizophrenia. There is growing evidence to suggest that the CB is actually comprised of a conglomeration of discrete sub-connections. The present study aimed to use Diffusion Tensor tractography to subdivide the CB into its constituent sub-connections, and to investigate the structural integrity of these sub-connections in patients with schizophrenia and matched healthy controls. Diffusion Tensor Imaging scans were acquired from 24 patients diagnosed with chronic schizophrenia and 26 matched healthy controls. Deterministic tractography was used in conjunction with FreeSurfer-based regions-of-interest to subdivide the CB into 5 sub-connections (I1 to I5). The patients with schizophrenia exhibited subnormal levels of FA in two cingulum sub-connections, specifically the fibers connecting the rostral and caudal anterior cingulate gyrus (I1) and the fibers connecting the isthmus of the cingulate with the parahippocampal cortex (I4). Furthermore, while FA in the I1 subconnection was correlated with the severity of patients' positive symptoms (specifically hallucinations and delusions), FA in the I4 sub-connection was correlated with the severity of patients' negative symptoms (specifically affective flattening and anhedonia/asociality). These results support the notion that the CB is a conglomeration of structurally interconnected yet functionally distinct sub-connections, of which only a subset are abnormal in patients with schizophrenia. Furthermore, while acknowledging the fact that the present study only investigated the CB, these results suggest that the positive and negative symptoms of schizophrenia may have distinct neurobiological underpinnings.

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