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Coping with Confounds in Multivoxel Pattern Analysis: What should We Do about Reaction Time Differences? A Comment on Todd, Nystrom & Cohen 2013.

Institution:
1Perception in Action Research Centre & Department of Cognitive Science, Faculty of Human Sciences, Macquarie University, Sydney, Australia. Electronic address: Alexandra.woolgar@mq.edu.au.
2Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.
3Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Australia.
Publisher:
Elsevier Science
Publication Date:
Sep-2014
Journal:
Neuroimage
Volume Number:
98
Pages:
506-12
Citation:
Neuroimage. 2014 Sep;98:506-12.
PubMed ID:
24793832
PMCID:
PMC4450346
Keywords:
Frontoparietal cortex, Modelling, Multivariate pattern analysis, Reaction time, Rule decoding, fMRI
Appears in Collections:
NAC, NA-MIC
Sponsors:
P41 EB015902/EB/NIBIB NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Woolgar A., Golland P., Bode S. Coping with Confounds in Multivoxel Pattern Analysis: What should We Do about Reaction Time Differences? A Comment on Todd, Nystrom & Cohen 2013.Neuroimage. 2014 Sep;98:506-12. PMID: 24793832. PMCID: PMC4450346.
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Multivoxel pattern analysis (MVPA) is a sensitive and increasingly popular method for examining differences between neural activation patterns that cannot be detected using classical mass-univariate analysis. Recently, Todd et al. ("Confounds in multivariate pattern analysis: Theory and rule representation case study", 2013, NeuroImage 77: 157-165) highlighted a potential problem for these methods: high sensitivity to confounds at the level of individual participants due to the use of directionless summary statistics. Unlike traditional mass-univariate analyses where confounding activation differences in opposite directions tend to approximately average out at group level, group level MVPA results may be driven by any activation differences that can be discriminated in individual participants. In Todd et al.'s empirical data, factoring out differences in reaction time (RT) reduced a classifier's ability to distinguish patterns of activation pertaining to two task rules. This raises two significant questions for the field: to what extent have previous multivoxel discriminations in the literature been driven by RT differences, and by what methods should future studies take RT and other confounds into account? We build on the work of Todd et al. and compare two different approaches to remove the effect of RT in MVPA. We show that in our empirical data, in contrast to that of Todd et al., the effect of RT on rule decoding is negligible, and results were not affected by the specific details of RT modelling. We discuss the meaning of and sensitivity for confounds in traditional and multivoxel approaches to fMRI analysis. We observe that the increased sensitivity of MVPA comes at a price of reduced specificity, meaning that these methods in particular call for careful consideration of what differs between our conditions of interest. We conclude that the additional complexity of the experimental design, analysis and interpretation needed for MVPA is still not a reason to favour a less sensitive approach.

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