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Does Diffusion MRI Tell Us Anything about the White Matter? An Overview of Methods and Pitfalls
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Institution: |
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: odonnell@bwh.harvard.edu. |
Publisher: |
Elsevier Science |
Publication Date: |
Jan-2015 |
Journal: |
Schizophr Res |
Volume Number: |
161 |
Issue Number: |
1 |
Pages: |
133-41 |
Citation: |
Schizophr Res. 2015 Jan;161(1):133-41. |
PubMed ID: |
25278106 |
PMCID: |
PMC4277728 |
Keywords: |
Clinical research, Diffusion MRI, Neuroimaging, Non-specificity, Tractography, White matter |
Appears in Collections: |
NCIGT, NAC, SLICER |
Sponsors: |
P41 EB015898/EB/NIBIB NIH HHS/United States P41 EB015902/EB/NIBIB NIH HHS/United States P41 RR013218/RR/NCRR NIH HHS/United States R01 MH074794/MH/NIMH NIH HHS/United States R01 MH102377/MH/NIMH NIH HHS/United States R21 CA156943/CA/NCI NIH HHS/United States |
Generated Citation: |
O'Donnell L., Pasternak O. Does Diffusion MRI Tell Us Anything about the White Matter? An Overview of Methods and Pitfalls. Schizophr Res. 2015 Jan;161(1):133-41. PMID: 25278106. PMCID: PMC4277728. |
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| Paper: | Download, View online |
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| Google Scholar: | link |
One key pitfall in diffusion magnetic resonance imaging (dMRI) clinical neuroimaging research is the challenge of understanding and interpreting the results of a complex analysis pipeline. The sophisticated algorithms employed by the analysis software, combined with the relatively non-specific nature of many diffusion measurements, lead to challenges in interpretation of the results. This paper is aimed at an intended audience of clinical researchers who are learning about dMRI or trying to interpret dMRI results, and who may be wondering "Does dMRI tell us anything about the white matter?" We present a critical review of dMRI methods and measures used in clinical neuroimaging research, focusing on the most commonly used analysis methods and the most commonly reported measures. We describe important pitfalls in every section, and provide extensive references for the reader interested in more detail.
Additional Material
1 File (63.646kB)
O'Donnell-SchizophrRes2015-fig2.jpg (63.646kB)