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Does Diffusion MRI Tell Us Anything about the White Matter? An Overview of Methods and Pitfalls

Institution:
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: odonnell@bwh.harvard.edu.
Publisher:
Elsevier Science
Publication Date:
Jan-2015
Journal:
Schizophr Res
Volume Number:
161
Issue Number:
1
Pages:
133-41
Citation:
Schizophr Res. 2015 Jan;161(1):133-41.
PubMed ID:
25278106
PMCID:
PMC4277728
Keywords:
Clinical research, Diffusion MRI, Neuroimaging, Non-specificity, Tractography, White matter
Appears in Collections:
NCIGT, NAC, SLICER
Sponsors:
P41 EB015898/EB/NIBIB NIH HHS/United States
P41 EB015902/EB/NIBIB NIH HHS/United States
P41 RR013218/RR/NCRR NIH HHS/United States
R01 MH074794/MH/NIMH NIH HHS/United States
R01 MH102377/MH/NIMH NIH HHS/United States
R21 CA156943/CA/NCI NIH HHS/United States
Generated Citation:
O'Donnell L., Pasternak O. Does Diffusion MRI Tell Us Anything about the White Matter? An Overview of Methods and Pitfalls. Schizophr Res. 2015 Jan;161(1):133-41. PMID: 25278106. PMCID: PMC4277728.
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One key pitfall in diffusion magnetic resonance imaging (dMRI) clinical neuroimaging research is the challenge of understanding and interpreting the results of a complex analysis pipeline. The sophisticated algorithms employed by the analysis software, combined with the relatively non-specific nature of many diffusion measurements, lead to challenges in interpretation of the results. This paper is aimed at an intended audience of clinical researchers who are learning about dMRI or trying to interpret dMRI results, and who may be wondering "Does dMRI tell us anything about the white matter?" We present a critical review of dMRI methods and measures used in clinical neuroimaging research, focusing on the most commonly used analysis methods and the most commonly reported measures. We describe important pitfalls in every section, and provide extensive references for the reader interested in more detail.

Additional Material
1 File (63.646kB)
O'Donnell-SchizophrRes2015-fig2.jpg (63.646kB)