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Cingulum Bundle Integrity Associated with Delusions of Control in Schizophrenia: Preliminary Evidence from Diffusion-tensor Tractography

Institution:
1School of Psychology, University of New South Wales, Sydney, NSW, Australia. Electronic address: t.whitford@unsw.edu.au.
2Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
3Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia.
4Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Harvard Medical School, Brockton, MA, USA.
Publisher:
Elsevier Science
Publication Date:
Jan-2015
Journal:
Schizophr Res
Volume Number:
161
Issue Number:
1
Pages:
36-41
Citation:
Schizophr Res. 2015 Jan;161(1):36-41.
PubMed ID:
25311780
PMCID:
PMC4303408
Keywords:
Cinglulum bundle, Delusions of control, Diffusion-Tensor Imaging (DTI), Passivity experiences, Schizophrenia, Tractography
Appears in Collections:
PNL, NA-MIC, SLICER
Sponsors:
K05 MH070047/MH/NIMH NIH HHS/United States
P50 MH080272/MH/NIMH NIH HHS/United States
R01 MH050747/MH/NIMH NIH HHS/United States
R01 MH040799/MH/NIMH NIH HHS/United States
R01 MH050740/MH/NIMH NIH HHS/United States
R01 MH102377/MH/NIMH NIH HHS/United States
R03 MH068464/MH/NIMH NIH HHS/United States
T32 MH016259/MH/NIMH NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Whitford T.J., Kubicki M., Pelavin P.E., Lucia D., Schneiderman J.S., Pantelis C., McCarley R.W., Shenton M.E. Cingulum Bundle Integrity Associated with Delusions of Control in Schizophrenia: Preliminary Evidence from Diffusion-tensor Tractography. Schizophr Res. 2015 Jan;161(1):36-41. PMID: 25311780. PMCID: PMC4303408.
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BACKGROUND: Delusions of control are among the most distinctive and characteristic symptoms of schizophrenia. Several theories have been proposed that implicate aberrant communication between spatially disparate brain regions in the etiology of this symptom. Given that white matter fasciculi represent the anatomical infrastructure for long-distance communication in the brain, the present study investigated whether delusions of control were associated with structural abnormalities in four major white matter fasciculi. METHODS: Ten schizophrenia patients with current delusions of control, 13 patients with no clinical history of delusions of control, and 12 healthy controls underwent a Diffusion-Tensor Imaging (DTI) scan. Deterministic tractography was used to extract the corpus callosum, superior longitudinal fasciculus, arcuate fasciculus, and cingulum bundle. The structural integrity of these four fasciculi was quantified with fractional anisotropy (FA) and compared between groups. RESULTS: The patients with delusions of control exhibited significantly lower FA in all four fasciculi, relative to the healthy controls. Furthermore, the patients with delusions of control also exhibited significantly lower FA in the cingulum bundle relative to patients without a history of this symptom, and this difference remained significant when controlling for between-group differences in global SAPS score and medication dosage. CONCLUSIONS: The results suggest that structural damage to the cingulum bundle may be involved in the etiology of delusions of control, possibly because of its role in connecting the action initiation areas of the premotor cortex with the cingulate gyrus.

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