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A Preliminary Study on the effect of Motion Correction on HARDI Reconstruction

Scientific Computing and Imaging Institute, Salt Lake City, UT, USA.
ISBI 2014
Publication Date:
Proc IEEE Int Symp Biomed Imaging
Volume Number:
Proc IEEE Int Symp Biomed Imaging. 2014 Apr;2014:1055-8.
Presented at:
ISBI 2014
PubMed ID:
Appears in Collections:
R01 HD055741/HD/NICHD NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Elhabian S., Gur Y., Vachet C., Piven J., Styner M., Leppert I., Pike G.B., Gerig G. A Preliminary Study on the effect of Motion Correction on HARDI Reconstruction. Proc IEEE Int Symp Biomed Imaging. 2014 Apr;2014:1055-8. PMID: 25356195. PMCID: PMC4209744.
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Post-acquisition motion correction is widely performed in diffusion-weighted imaging (DWI) to guarantee voxel-wise correspondence between DWIs. Whereas this is primarily motivated to save as many scans as possible if corrupted by motion, users do not fully understand the consequences of different types of interpolation schemes on the final analysis. Nonetheless, interpolation might increase the partial volume effect while not preserving the volume of the diffusion profile, whereas excluding poor DWIs may affect the ability to resolve crossing fibers especially with small separation angles. In this paper, we investigate the effect of interpolating diffusion measurements as well as the elimination of bad directions on the reconstructed fiber orientation diffusion functions and on the estimated fiber orientations. We demonstrate such an effect on synthetic and real HARDI datasets. Our experiments demonstrate that the effect of interpolation is more significant with small fibers separation angles where the exclusion of motion-corrupted directions decreases the ability to resolve such crossing fibers.

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