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A Joint Framework for 4D Segmentation and Estimation of Smooth Temporal Appearance Changes

1Scientific Computing and Imaging Institute, School of Computing, University of Utah, Salt Lake City, UT, USA.
2Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
ISBI 2014
Publication Date:
Proc IEEE Int Symp Biomed Imaging
Volume Number:
Proc IEEE Int Symp Biomed Imaging. 2014 Apr;2014:1291-4.
PubMed ID:
Appears in Collections:
P50 MH064065/MH/NIMH NIH HHS/United States
R01 HD055741/HD/NICHD NIH HHS/United States
R01 MH070890/MH/NIMH NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Gao Y., Prastawa M., Styner M., Piven J., Gerig G. A Joint Framework for 4D Segmentation and Estimation of Smooth Temporal Appearance Changes. Proc IEEE Int Symp Biomed Imaging. 2014 Apr;2014:1291-4. PMID: 25356196. PMCID: PMC4209703.
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Medical imaging studies increasingly use longitudinal images of individual subjects in order to follow-up changes due to development, degeneration, disease progression or efficacy of therapeutic intervention. Repeated image data of individuals are highly correlated, and the strong causality of information over time lead to the development of procedures for joint segmentation of the series of scans, called 4D segmentation. A main aim was improved consistency of quantitative analysis, most often solved via patient-specific atlases. Challenging open problems are contrast changes and occurrance of subclasses within tissue as observed in multimodal MRI of infant development, neurodegeneration and disease. This paper proposes a new 4D segmentation framework that enforces continuous dynamic changes of tissue contrast patterns over time as observed in such data. Moreover, our model includes the capability to segment different contrast patterns within a specific tissue class, for example as seen in myelinated and un-myelinated white matter regions in early brain development. Proof of concept is shown with validation on synthetic image data and with 4D segmentation of longitudinal, multimodal pediatric MRI taken at 6, 12 and 24 months of age, but the methodology is generic w.r.t. different application domains using serial imaging.

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