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Multivariate Longitudinal Shape Analysis of Human Lateral Ventricles during the First Twenty-Four Months of Life

Institution:
1Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
2Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
3Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
4Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.
5Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Publisher:
Public Library of Science
Publication Date:
Sep-2014
Journal:
PLoS One
Volume Number:
9
Issue Number:
9
Pages:
e108306
Citation:
PLoS One. 2014 Sep 29;9(9):e108306.
PubMed ID:
25265017
PMCID:
PMC4180454
Appears in Collections:
NA-MIC, SLICER
Sponsors:
R01 NS055754/NS/NINDS NIH HHS/United States
UL1 RR025747/RR/NCRR NIH HHS/United States
P01 CA142538/CA/NCI NIH HHS/United States
R01 MH086633/MH/NIMH NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Bompard L., Xu S., Styner M., Paniagua B., Ahn M., Yuan Y., Jewells V., Gao W., Shen D., Zhu H., Lin W. Multivariate Longitudinal Shape Analysis of Human Lateral Ventricles during the First Twenty-Four Months of Life. PLoS One. 2014 Sep 29;9(9):e108306. PMID: 25265017. PMCID: PMC4180454.
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Little is known about the temporospatial shape characteristics of human lateral ventricles (LVs) during the first two years of life. This study aimed to delineate the morphological growth characteristics of LVs during early infancy using longitudinally acquired MR images in normal healthy infants. METHODS: 24 healthy infants were MR imaged starting from 2 weeks old every 3 months during the first and every 6 months during the second year. Bilateral LVs were segmented and longitudinal morphological and shape analysis were conducted using longitudinal mixed effect models. RESULTS: A significant bilateral ventricular volume increase (p<0.0001) is observed in year one (Left: 126±51% and Right: 145±62%), followed by a significant reduction (p<0.02) during the second year of life (Left: -24±27% and Right: -20±18%) despite the continuing increase of intracranial volume. Morphological analysis reveals that the ventricular growth is spatially non-uniform, and that the most significant growth occurs during the first 6 months. The first 3 months of life exhibit a significant (p<0.01) bilateral lengthening of the anterior lateral ventricle and a significant increase of radius (p<0.01) and area (p<0.01) at the posterior portion of the ventricle. Shape analysis shows that the horns exhibit a faster growth rate than the mid-body. Finally, bilateral significant age effects (p<0.01) are observed for the growth of LVs whereas gender effects are more subtle and significant effects (p<0.01) only present at the left anterior and posterior horns. More importantly, both the age and gender effects are growth directionally dependent. CONCLUSIONS: We have demonstrated the temporospatial shape growth characteristics of human LVs during the first two years of life using a unique longitudinal MR data set. A temporally and spatially non-uniform growth pattern was reported. These normative results could provide invaluable information to discern abnormal growth patterns in patients with neurodevelopmental disorders.

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