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The DTI Connectivity of the Human Claustrum

Institution:
The Institute for Neuroimaging and Informatics (INI) and Laboratory of Neuro Imaging [LONI], Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Publisher:
John Wiley & Sons, Inc.
Publication Date:
Mar-2015
Journal:
Hum Brain Mapp
Volume Number:
36
Issue Number:
3
Pages:
827-38
Citation:
Hum Brain Mapp. 2015 Mar;36(3):827-38.
PubMed ID:
25339630
PMCID:
PMC4324054
Keywords:
brain networks, claustrum, cognition, connectivity, consciousness, cortex, diffusion tensor imaging, graph theory, magnetic resonance imaging, neurology
Appears in Collections:
NA-MIC, SLICER
Sponsors:
P41 EB015922/EB/NIBIB NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Torgerson C.M., Irimia A., Goh S.Y.M., Van Horn J.D. The DTI Connectivity of the Human Claustrum. Hum Brain Mapp. 2015 Mar;36(3):827-38. PMID: 25339630. PMCID: PMC4324054.
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The origin, structure, and function of the claustrum, as well as its role in neural computation, have remained a mystery since its discovery in the 17th century. Assessing the in vivo connectivity of the claustrum may bring forth useful insights with relevance to model the overall functionality of the claustrum itself. Using structural and diffusion tensor neuroimaging in N = 100 healthy subjects, we found that the claustrum has the highest connectivity in the brain by regional volume. Network theoretical analyses revealed that (a) the claustrum is a primary contributor to global brain network architecture, and that (b) significant connectivity dependencies exist between the claustrum, frontal lobe, and cingulate regions. These results illustrate that the claustrum is ideally located within the human central nervous system (CNS) connectome to serve as the putative "gate keeper" of neural information for consciousness awareness. Our findings support and underscore prior theoretical contributions about the involvement of the claustrum in higher cognitive function and its relevance in devastating neurological disease.

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