Surgical Planning Laboratory - Brigham & Women's Hospital - Boston, Massachusetts USA - a teaching affiliate of Harvard Medical School

Surgical Planning Laboratory

The Publication Database hosted by SPL

All Publications | Upload | Advanced Search | Gallery View | Download Statistics | Help | Import | Log in

Spherical Topic Models for Imaging Phenotype Discovery in Genetic Studies

Institution:
1Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.
2Surgical Planning Laboratory, Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
Publication Date:
Feb-2014
Journal:
Bayesian Graph Models Biomed Imaging
Volume Number:
8677
Pages:
107-17
Citation:
Bayesian Graph Models Biomed Imaging. 2014 Feb; 8677: 107-17.
PubMed ID:
25717477
PMCID:
PMC4337963
Appears in Collections:
NAC, NA-MIC
Sponsors:
U54 EB005149/EB/NIBIB NIH HHS/United States
P41 RR013218/RR/NCRR NIH HHS/United States
P41 EB015902/EB/NIBIB NIH HHS/United States
R01 HL089856/HL/NHLBI NIH HHS/United States
R01 HL089897/HL/NHLBI NIH HHS/United States
K08 HL097029/HL/NHLBI NIH HHS/United States
R01 HL113264/HL/NHLBI NIH HHS/United States
Generated Citation:
Batmanghelich K.N., Cho M., San Jose R., Golland P. Spherical Topic Models for Imaging Phenotype Discovery in Genetic Studies. Bayesian Graph Models Biomed Imaging. 2014 Feb; 8677: 107-17. PMID: 25717477. PMCID: PMC4337963.
Downloaded: 802 times. [view map]
Paper: Download, View online
Export citation:
Google Scholar: link

In this paper, we use Spherical Topic Models to discover the latent structure of lung disease. This method can be widely employed when a measurement for each subject is provided as a normalized histogram of relevant features. In this paper, the resulting descriptors are used as phenotypes to identify genetic markers associated with the Chronic Obstructive Pulmonary Disease (COPD). Features extracted from images capture the heterogeneity of the disease and therefore promise to improve detection of relevant genetic variants in Genome Wide Association Studies (GWAS). Our generative model is based on normalized histograms of image intensity of each subject and it can be readily extended to other forms of features as long as they are provided as normalized histograms. The resulting algorithm represents the intensity distribution as a combination of meaningful latent factors and mixing co-efficients that can be used for genetic association analysis. This approach is motivated by a clinical hypothesis that COPD symptoms are caused by multiple coexisting disease processes. Our experiments show that the new features enhance the previously detected signal on chromosome 15 with respect to standard respiratory and imaging measurements.

Additional Material
1 File (56.932kB)
Batmanghelich-BGMBI2014-fig2.jpg (56.932kB)