Surgical Planning Laboratory - Brigham & Women's Hospital - Boston, Massachusetts USA - a teaching affiliate of Harvard Medical School

Surgical Planning Laboratory

The Publication Database hosted by SPL

All Publications | Upload | Advanced Search | Gallery View | Download Statistics | Help | Import | Log in

Diagnostic Index of 3D Osteoarthritic Changes in TMJ Condylar Morphology

1University of Michigan, Ann Arbor, MI, USA.
2University of North Carolina, Chapel Hill, NC, USA.
3UNESP Univ Estadual Paulista, Araraquara, SP, Brazil.
Publication Date:
SPIE 2015 Feb;
Temporomandibular Joint Disorders, Osteoarthritis, Bone Resorption, Bone Overgrowth, 3D imaging
Appears in Collections:
R01 DE024450/DE/NIDCR NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Gomes L.R., Gomes M., Jung B., Paniagua B., Ruellas A.C., Gonçalves J.R., Styner M.A., Cevidanes L.H. Diagnostic Index of 3D Osteoarthritic Changes in TMJ Condylar Morphology. SPIE 2015 Feb;
Downloaded: 997 times. [view map]
Paper: Download, View online
Export citation:
Google Scholar: link

The aim of this study was to investigate imaging statistical approaches for classifying 3D osteoarthritic morphological variations among 169 Temporomandibular Joint (TMJ) condyles. Cone beam Computed Tomography (CBCT) scans were acquired from 69 patients with long-term TMJ Osteoarthritis (OA) (39.1 ± 15.7 years), 15 patients at initial diagnosis of OA (44.9 ± 14.8 years) and 7 healthy controls (43 ± 12.4 years). 3D surface models of the condyles were constructed and Shape Correspondence was used to establish correspondent points on each model. The statistical framework included a multivariate analysis of covariance (MANCOVA) and Direction-Projection- Permutation (DiProPerm) for testing statistical significance of the differences between healthy control and the OA group determined by clinical and radiographic diagnoses. Unsupervised classification using hierarchical agglomerative clustering (HAC) was then conducted. Condylar morphology in OA and healthy subjects varied widely. Compared with healthy controls, OA average condyle was statistically significantly smaller in all dimensions except its anterior surface. Significant flattening of the lateral pole was noticed at initial diagnosis (p < 0.05). It was observed areas of 3.88 mm bone resorption at the superior surface and 3.10 mm bone apposition at the anterior aspect of the long-term OA average model. 1000 permutation statistics of DiProPerm supported a significant difference between the healthy control group and OA group (t = 6.7, empirical p-value = 0.001). Clinically meaningful unsupervised classification of TMJ condylar morphology determined a preliminary diagnostic index of 3D osteoarthritic changes, which may be the first step towards a more targeted diagnosis of this condition.

Additional Material
1 File (110.011kB)
Gomes-JMI-SPIE2015-fig1.jpg (110.011kB)