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Occipital Lobe Gray Matter Volume in Male Patients with Chronic Schizophrenia: A Quantitative MRI Study

Institution:
Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division and Harvard Medical School, Brockton, MA, USA.
Publisher:
Schizophr Res
Publication Date:
May-2007
Volume Number:
92
Issue Number:
1-3
Pages:
197-206
Citation:
Schizophr Res. 2007 May;92(1-3):197-206.
PubMed ID:
17350226
PMCID:
PMC2396445
Keywords:
High-spatial Resolution MRI, Schizophrenia, Primary visual area, Visual association areas, Quantitative MRI
Appears in Collections:
PNL, NA-MIC, NAC, NCIGT, SLICER, SPL
Sponsors:
K02 MH001110/MH/NIMH NIH HHS/United States
K05 MH070047/MH/NIMH NIH HHS/United States
R01 MH040799/MH/NIMH NIH HHS/United States
R01 MH050747/MH/NIMH NIH HHS/United States
R01 MH050740/MH/NIMH NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
Generated Citation:
Onitsuka T., McCarley R.W., Kuroki N., Dickey C.C., Kubicki M., Demeo S.S., Frumin M., Kikinis R., Jolesz F.A., Shenton M.E. Occipital Lobe Gray Matter Volume in Male Patients with Chronic Schizophrenia: A Quantitative MRI Study. Schizophr Res. 2007 May;92(1-3):197-206. PMID: 17350226. PMCID: PMC2396445.
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Schizophrenia is characterized by deficits in cognition as well as visual perception. There have, however, been few magnetic resonance imaging (MRI) studies of the occipital lobe as an anatomically defined region of interest in schizophrenia. To examine whether or not patients with chronic schizophrenia show occipital lobe volume abnormalities, we measured gray matter volumes for both the primary visual area (PVA) and the visual association areas (VAA) using MRI based neuroanatomical landmarks and three-dimensional information. PVA and VAA gray matter volumes were measured using high-spatial resolution MRI in 25 male patients diagnosed with chronic schizophrenia and in 28 male normal controls. Chronic schizophrenia patients showed reduced bilateral VAA gray matter volume (11%), compared with normal controls, whereas patients showed no group difference in PVA gray matter volume. These results suggest that reduced bilateral VAA may be a neurobiological substrate of some of the deficits observed in early visual processing in schizophrenia.

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