The Publication Database hosted by SPL
|
All Publications
Upload
Advanced Search
Gallery View
Download Statistics
Help
Import
Log in
Occipital Lobe Gray Matter Volume in Male Patients with Chronic Schizophrenia: A Quantitative MRI Study
|
|
Onitsuka T., McCarley R.W., Kuroki N., Dickey C.C., Kubicki M., Demeo S.S., Frumin M., Kikinis R., Jolesz F.A., Shenton M.E.
Institution: |
Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division and Harvard Medical School, Brockton, MA, USA. |
Publisher: |
Schizophr Res |
Publication Date: |
May-2007 |
Volume Number: |
92 |
Issue Number: |
1-3 |
Pages: |
197-206 |
Citation: |
Schizophr Res. 2007 May;92(1-3):197-206. |
PubMed ID: |
17350226 |
PMCID: |
PMC2396445 |
Keywords: |
High-spatial resolution MRI, Schizophrenia, Primary visual area, Visual association areas, Quantitative MRI |
Appears in Collections: |
PNL, NA-MIC, NAC, NCIGT, SLICER, SPL |
Sponsors: |
K02 MH01110/MH/NIMH NIH HHS/United States K05 MH070047-04/MH/NIMH NIH HHS/United States K05 MH070047-05/MH/NIMH NIH HHS/United States R01 MH40799/MH/NIMH NIH HHS/United States R01 MH050747/MH/NIMH NIH HHS/United States R01 MH050740-13/MH/NIMH NIH HHS/United States U54 EB005149/EB/NIBIB NIH HHS/United States |
Generated Citation: |
Onitsuka T., McCarley R.W., Kuroki N., Dickey C.C., Kubicki M., Demeo S.S., Frumin M., Kikinis R., Jolesz F.A., Shenton M.E. Occipital Lobe Gray Matter Volume in Male Patients with Chronic Schizophrenia: A Quantitative MRI Study. Schizophr Res. 2007 May;92(1-3):197-206. PMID: 17350226. PMCID: PMC2396445. |
| Downloaded: | 2141 times. [view map] |
| Paper: | Download, View online |
| Export citation: |
Schizophrenia is characterized by deficits in cognition as well as visual perception. There have, however, been few magnetic resonance imaging (MRI) studies of the occipital lobe as an anatomically defined region of interest in schizophrenia. To examine whether or not patients with chronic schizophrenia show occipital lobe volume abnormalities, we measured gray matter volumes for both the primary visual area (PVA) and the visual association areas (VAA) using MRI based neuroanatomical landmarks and three-dimensional information. PVA and VAA gray matter volumes were measured using high-spatial resolution MRI in 25 male patients diagnosed with chronic schizophrenia and in 28 male normal controls. Chronic schizophrenia patients showed reduced bilateral VAA gray matter volume (11%), compared with normal controls, whereas patients showed no group difference in PVA gray matter volume. These results suggest that reduced bilateral VAA may be a neurobiological substrate of some of the deficits observed in early visual processing in schizophrenia.
Additional Material
1 File (352.542kB)
Onitsuka-SchizRes2007-fig1.jpg (352.542kB)