Surgical Planning Laboratory - Brigham & Women's Hospital - Boston, Massachusetts USA - a teaching affiliate of Harvard Medical School

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Reconstruction of the Arcuate Fasciculus for Surgical Planning in the Setting of Peritumoral Edema using Two-tensor Unscented Kalman Filter Tractography

Institution:
1Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
2Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
3Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Publication Date:
Mar-2015
Volume Number:
7
Pages:
815-22
Citation:
NeuroImage: Clinical 2015 Mar; 7:815-22.
PubMed ID:
26082890
PMCID:
PMC4459040
Keywords:
Arcuate fasciculus, Diffusion tensor imaging , Peritumoral edema, Tractography, Neurosurgical planning
Appears in Collections:
NCIGT, NAC, SLICER
Sponsors:
R21 CA156943/CA/NCI NIH HHS/United States
P41 EB015898/EB/NIBIB NIH HHS/United States
R21 NS075728/NS/NINDS NIH HHS/United States
P41 EB015902/EB/NIBIB NIH HHS/United States
R01 MH074794/MH/NIMH NIH HHS/United States
R01 MH092862/MH/NIMH NIH HHS/United States
R01 MH097979/MH/NIMH NIH HHS/United States
U01 NS083223/NS/NINDS NIH HHS/United States
Generated Citation:
Chen Z., Tie Y., Olubiyi O., Rigolo L., Mehrtash A., Norton I., Pasternak O., Rathi Y., Golby A.J., O'Donnell L. Reconstruction of the Arcuate Fasciculus for Surgical Planning in the Setting of Peritumoral Edema using Two-tensor Unscented Kalman Filter Tractography. NeuroImage: Clinical 2015 Mar; 7:815-22. PMID: 26082890. PMCID: PMC4459040.
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Background: Diffusion imaging tractography is increasingly used to trace critical fiber tracts in brain tumor patients to reduce the risk of post-operative neurological deficit. However, the effects of peritumoral edema pose a challenge to conventional tractography using the standard diffusion tensor model. The aim of this study was to present a novel technique using a two-tensor unscented Kalman filter (UKF) algorithm to track the arcuate fasciculus (AF) in brain tumor patients with peritumoral edema. Methods: Ten right-handed patients with left-sided brain tumors in the vicinity of language-related cortex and evidence of significant peritumoral edema were retrospectively selected for the study. All patients underwent 3-Tesla magnetic resonance imaging (MRI) including a diffusion-weighted dataset with 31 directions. Fiber tractography was performed using both single-tensor streamline and two-tensor UKF tractography. A two regions-of-interest approach was applied to perform the delineation of the AF. Results from the two different tractography algorithms were compared visually and quantitatively. Results: Using single-tensor streamline tractography, the AF appeared disrupted in four patients and contained few fibers in the remaining six patients. Two-tensor UKF tractography delineated an AF that traversed edematous brain areas in all patients. The volume of the AF was significantly larger on two-tensor UKF than on single-tensor streamline tractography (p b 0.01). Conclusions: Two-tensor UKF tractography provides the ability to trace a larger volume AF than single-tensor streamline tractography in the setting of peritumoral edema in brain tumor patients.

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