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Shape Index Distribution Based Local Surface Complexity Applied to the Human Cortex

Institution:
1Department of Psychiatry, University of North Carolina at Chapel Hill, NC, USA.
2McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, QC, Canada.
3Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, USA.
Publication Date:
Mar-2015
Journal:
Proc SPIE Int Soc Opt Eng
Volume Number:
9413
Pages:
941344
Citation:
Proc SPIE Int Soc Opt Eng. 2015 Mar;9413:941344.
PubMed ID:
26028803
PMCID:
PMC4449152
Keywords:
Earth Move Distance, Local Shape Complexity Index, Shape Index
Appears in Collections:
NA-MIC
Sponsors:
P30 HD003110/HD/NICHD NIH HHS/United States
R01 HD053000/HD/NICHD NIH HHS/United States
R01 HD055741/HD/NICHD NIH HHS/United States
R01 MH070890/MH/NIMH NIH HHS/United States
R01 MH091645/MH/NIMH NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
U54 HD079124/HD/NICHD NIH HHS/United States
Generated Citation:
Kim S.H., Fonov V., Collins D.L., Gerig G., Styner M.A. Shape Index Distribution Based Local Surface Complexity Applied to the Human Cortex. Proc SPIE Int Soc Opt Eng. 2015 Mar;9413:941344. PMID: 26028803. PMCID: PMC4449152.
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The quantification of local surface complexity in the human cortex has shown to be of interest in investigating population differences as well as developmental changes in neurodegenerative or neurodevelopment diseases. We propose a novel assessment method that represents local complexity as the difference between the observed distributions of local surface topology to its best-fit basic topology model within a given local neighborhood. This distribution difference is estimated via Earth Move Distance (EMD) over the histogram within the local neighborhood of the surface topology quantified via the Shape Index (SI) measure. The EMD scores have a range from simple complexity (0.0), which indicates a consistent local surface topology, up to high complexity (1.0), which indicates a highly variable local surface topology. The basic topology models are categorized as 9 geometric situation modeling situations such as crowns, ridges and fundi of cortical gyro and sulci. We apply a geodesic kernel to calculate the local SI histogram distribution within a given region. In our experiments, we obtained the results of local complexity that shows generally higher complexity in the gyral/sulcal wall regions and lower complexity in some gyral ridges and lowest complexity in sulcal fundus areas. In addition, we show expected, preliminary results of increased surface complexity across most of the cortical surface within the first years of postnatal life, hypothesized to be due to the changes such as development of sulcal pits.

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