Surgical Planning Laboratory - Brigham & Women's Hospital - Boston, Massachusetts USA - a teaching affiliate of Harvard Medical School

Surgical Planning Laboratory

The Publication Database hosted by SPL

All Publications | Upload | Advanced Search | Gallery View | Download Statistics | Help | Import | Log in

Longitudinal Qantification and Visualization of Intracerebral Haemorrhage using Multimodal Magnetic Resonance and Diffusion Tensor Imaging

Institution:
Institute for Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Publisher:
Informa Healthcare
Publication Date:
May-2015
Journal:
Brain Inj
Volume Number:
29
Issue Number:
4
Pages:
438-45
Citation:
Brain Inj. 2015 May;29(4):438-45.
PubMed ID:
25518865
PMCID:
PMC4440338
Keywords:
Diffusion tensor imaging, intracerebral haemorrhagE, longitudinal study, magnetic resonance imaging
Appears in Collections:
NA-MIC, SLICER
Sponsors:
U54 EB005149/EB/NIBIB NIH HHS/United States
P01 NS058489/NS/NINDS NIH HHS/United States
R41 NS081792/NS/NINDS NIH HHS/United States
Generated Citation:
Goh S.Y.M., Irimia A., Torgerson C.M., Tubi M.A., Real C.R., Hanley D.F., Martin N.A., Vespa P.M., Van Horn J.D. Longitudinal Qantification and Visualization of Intracerebral Haemorrhage using Multimodal Magnetic Resonance and Diffusion Tensor Imaging. Brain Inj. 2015 May;29(4):438-45. PMID: 25518865. PMCID: PMC4440338.
Downloaded: 676 times. [view map]
Paper: Download, View online
Export citation:
Google Scholar: link

OBJECTIVE: To demonstrate a set of approaches using diffusion tensor imaging (DTI) tractography whereby pathology-affected white matter (WM) fibres in patients with intracerebral haemorrhage (ICH) can be selectively visualized. METHODS: Using structural neuroimaging and DTI volumes acquired longitudinally from three representative patients with ICH, the spatial configuration of ICH-related trauma is delineated and the WM fibre bundles intersecting each ICH lesion are identified and visualized. Both the extent of ICH lesions as well as the proportion of WM fibres intersecting the ICH pathology are quantified and compared across subjects. RESULTS: This method successfully demonstrates longitudinal volumetric differences in ICH lesion load and differences across time in the percentage of fibres which intersect the primary injury. CONCLUSIONS: Because neurological conditions such as intracerebral haemorrhage (ICH) frequently exhibit pathology-related effects which lead to the exertion of mechanical pressure upon surrounding tissues and, thereby, to the deformation and/or displacement of WM fibres, DTI fibre tractography is highly suitable for assessing longitudinal changes in WM fibre integrity and mechanical displacement.

Additional Material
1 File (110.689kB)
Goh-BrainInj2015-fig4.jpg (110.689kB)