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Systematic Network Lesioning Reveals the Core White Matter Scaffold of the Human Brain

Institution:
Department of Neurology, Keck School of Medicine, Institute for Neuroimaging and Informatics, University of Southern California Los Angeles, CA, USA.
Publisher:
Frontiers Media SA
Publication Date:
Feb-2014
Journal:
Front Hum Neurosci
Volume Number:
8
Pages:
51
Citation:
Front Hum Neurosci. 2014 Feb 11;8:51.
PubMed ID:
24574993
PMCID:
PMC3920080
Keywords:
connectomics, traumaticbraininjury, brainnetwork, neurotrauma, neuroimaging, MRI, DTI
Appears in Collections:
NA-MIC
Sponsors:
P41 EB015922/EB/NIBIB NIH HHS/United States
U54 EB005149/EB/NIBIB NIH HHS/United States
RC1 MH088194/MH/NIMH NIH HHS/United States
R41 NS081792/NS/NINDS NIH HHS/United States
Generated Citation:
Irimia A., Van Horn J.D. Systematic Network Lesioning Reveals the Core White Matter Scaffold of the Human Brain. Front Hum Neurosci. 2014 Feb 11;8:51. PMID: 24574993. PMCID: PMC3920080.
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Brain connectivity loss due to traumatic brain injury, stroke or multiple sclerosis can have serious consequences on life quality and a measurable impact upon neural and cognitive function. Though brain network properties are known to be affected disproportionately by injuries to certain gray matter regions, the manner in which white matter (WM) insults affect such properties remains poorly understood. Here, network-theoretic analysis allows us to identify the existence of a macroscopic neural connectivity core in the adult human brain which is particularly sensitive to network lesioning. The systematic lesion analysis of brain connectivity matrices from diffusion neuroimaging over a large sample (N = 110) reveals that the global vulnerability of brain networks can be predicated upon the extent to which injuries disrupt this connectivity core, which is found to be quite distinct from the set of connections between rich club nodes in the brain. Thus, in addition to connectivity within the rich club, the brain as a network also contains a distinct core scaffold of network edges consisting of WM connections whose damage dramatically lowers the integrative properties of brain networks. This pattern of core WM fasciculi whose injury results in major alterations to overall network integrity presents new avenues for clinical outcome prediction following brain injury by relating lesion locations to connectivity core disruption and implications for recovery. The findings of this study contribute substantially to current understanding of the human WM connectome, its sensitivity to injury, and clarify a long-standing debate regarding the relative prominence of gray vs. WM regions in the context of brain structure and connectomic architecture.

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